Watch CBS News
The drug - called CM4620-IE - received fast-track approval from the FDA earlier this month, allowing HealthPartners to begin clinical trials.
Virginia-based Smithfield Foods announced Sunday that it is closing its pork processing plant in Sioux Falls until further notice after hundreds of employees tested positive for the coronavirus — a step the head of the company warned could hurt the nation's meat supply.
Neel Kashkari, president of the Federal Reserve Bank of Minneapolis, projects tough times ahead -- barring a healthcare miracle.
For St. Ambrose in Woodbury, the sunrise mass featured Pastor Peter Williams in a beanie and gloves, three singers, a flutist, and a piano player outside in the freezing cold and snow
Inmates in Minnesota Correctional Faculty – Moose Lake are under a "Stay with Unit" plan due to an outbreak of the coronavirus that has sickened about three dozen inmates.
Here are the latest updates in the COVID-19 pandemic.
The actual amount of COVID-19 infections could be significantly higher, as testing has been seriously limited across the country.
There's now an added layer of protection for first responders working during this pandemic. Gov. Walz signed an executive order on Friday that allows 911 dispatch centers to have access to health department data showing where positive COVID cases are located in the state.
U.S. Senators Amy Klobuchar and Tina Smith announced Saturday that the Department of Transportation (DOT) has awarded Minnesota over $306 million for public transit infrastructure funding in response to the COVID-19 pandemic.
To help prevent the spread of COVID-19, you are encouraged to wash your hands frequently and avoid touching your eyes or nose unnecessarily.
The lawsuit seeks unspecified monetary damages as well as all profits derived from the alleged scheme, which 3M said it plans to donate to COVID-19 charitable organizations.
"Our number one seller is home-defense shotguns," said Kory Krause, who owns Frontiersman gun store in St. Louis Park, Minnesota.
The Minnesota Department of Natural Resources (DNR) has temporarily closed Grand Portage State Park along the Canadian border on the North Shore of Lake Superior.
Can you imagine if your phone could tell you if you may have been exposed to someone with COVID-19? Two tech giants are working together on that right now.
Minnesota Governor Tim Walz has said the information from state's COVID-19 modeling is one of the major considerations in the stay-at-home order.
The University of Minnesota President Joan Gabel sent out a systemwide message on Friday to all students, staff and faculty regarding a virtual celebration for 2020 graduates.
One of the latest to die from COVID-19 is a 38-year-old dad, brother, uncle and son. Josh Pearson's mom told us his symptoms came on fast and by the time a hospital agreed to see him, it was too late.
A letter from the Minnesota Hospital Association to the state's Congressional delegation paints a dire financial picture. Losses are estimated at $2.9 billion over the next 90 days.
Leaders will continue to look to the models as a guide, and they say we can expect more refinement and enhancing of the formula in the coming weeks.
At 23,000 members strong, it's all about providing health care workers a way to isolate from family, without having to leave their property.
The employee did not operate a Metro Transit vehicle with the general public on board.
In a show of support for Minnesotans who are united in their fight against the coronavirus pandemic, the Split Rock Lighthouse on Lake Superior's north shore will light its beacon.
COVID-19 has claimed seven more lives in Minnesota, bringing the state's death toll to 57.
It's unknown when Mayo Clinic's operations will be back to normal.
In an interview with Christiane Cordero, Mayor Carter explains how decisions are made in the COVID-19 era, the city's plan to enforce social distancing, and where he hopes to see progress against the pandemic.
Macklin Celebrini had a goal and an assist hours after being selected to play for Team Canada at the 2026 Winter Olympics, and the San Jose Sharks beat the Minnesota Wild 4–3 in a shootout.
Paid leave officially launched in Minnesota, two and a half years after Governor Walz signed the bill.
Advocates and providers are warning that if federal funding is withheld, legitimate day cares in Minnesota won't be able to survive.
The Minnesota Assistance Council for Veterans doesn't quit trying to help service members — even when a veteran gives up on themselves.
The Steele County Sheriff's Office is asking for help in finding a missing teenager, last seen in early December.
Paid leave officially launched in Minnesota, two and a half years after Governor Walz signed the bill.
The Minnesota Assistance Council for Veterans doesn't quit trying to help service members — even when a veteran gives up on themselves.
The Steele County Sheriff's Office is asking for help in finding a missing teenager, last seen in early December.
There were 584 vehicles towed during this week's snow emergency in Minneapolis. That number stands at 352 and counting in St. Paul, where parking restrictions are in place until 9 p.m. on Friday, Jan. 2.
On Dec. 16, 2025, security footage shows various people throughout the day dropping off young children at the state-licensed ABC Learning Center in Minneapolis. That same day, YouTuber Nick Shirley arrived and claimed that the day care was among many in Minnesota that were empty.
The Steele County Sheriff's Office is asking for help in finding a missing teenager, last seen in early December.
Family and friends are mourning a young mother and long-time waitress who lost her life on Christmas Eve.
After spending Christmas in the hospital, a high school wrestler who was shot will get to ring in the new year at home.
A grocery store worker on Minnesota's North Shore is charged with attempted murder after allegedly stabbing a customer in the neck on Saturday afternoon while in the midst of a mental health crisis.
Two Minnesota lawmakers and their loved ones attacked in their homes, federal immigration enforcement operations targeting Somali immigrants and fraud investigations were some of Minnesota's top political stories in 2025.
Two people were killed and another hurt in a crash in western Wisconsin Tuesday afternoon.
A Wisconsin woman who almost killed her sixth-grade classmate to please the fictional Slender Man has been ordered back to a state psychiatric hospital after she escaped from her group home last month.
Several schools in Minnesota and Wisconsin are reporting delayed starts on Monday amid a messy morning commute.
The U.S. Justice Department has sued three states, including Illinois and Wisconsin, and D.C. for not turning over requested voter information to the Trump administration.
Defenders of a Wisconsin judge found guilty of felony obstruction for helping a Mexican immigrant evade federal officers are raising alarms about judicial independence and say they hope the conviction will be overturned on appeal.
Many people who serve in the U.S. military find it hard to ask for assistance when they've been trained to help and serve others.
Food Bank Eatery in North Minneapolis provides free meals for children, who may have little to eat after the pause of SNAP benefits for many in the community.
Firefighters are continuing a 44-year tradition that happens every year north of the Twin Cities.
It was a scary moment in the Twin Cities over the weekend, as a trailer hauling sled dogs turned over on Interstate 494 in Minnetonka.
On Sunday, members of Minnesota's Somali community spoke out against President Trump's social media post calling for an end to temporary protected status.
Paid leave officially launched in Minnesota, two and a half years after Governor Walz signed the bill.
Advocates and providers are warning that if federal funding is withheld, legitimate day cares in Minnesota won't be able to survive.
A viral social media video has put Minnesota's long-running fraud scandal at the center of the national conversation. Here's what to know.
A Minneapolis day care says that vandals damaged the facility early this week, after a YouTube video purporting to expose fraud among day cares in the Twin Cities metro area went viral.
House Oversight and Government Reform Committee Chairman James Comer said the hearing will take place Jan. 7.
There were 584 vehicles towed during this week's snow emergency in Minneapolis. That number stands at 352 and counting in St. Paul, where parking restrictions are in place until 9 p.m. on Friday, Jan. 2.
While no illness has been reported so far, the U.S. Food and Drug Administration says 54 stores in the state were affected by Gold Star Distribution's recall.
This season of giving can really do a number on our recycling systems. But we can all be part of the solution.
With the time-honored tradition of gift giving comes gift concealing.
Twin Cities shoppers were out and about on Super Saturday, the second-busiest shopping day of the year. The day lands on the final Saturday before Christmas annually.
A Minneapolis day care says that vandals damaged the facility early this week, after a YouTube video purporting to expose fraud among day cares in the Twin Cities metro area went viral.
The ringleader of what authorities called the largest pandemic fraud case in the United States has been ordered to forfeit more than $5 million.
Twin Cities police say they believe there could be more victims of a 37-year-old man charged earlier this month with child sex crimes.
Broken Clock Brewing Cooperative is a tap room, a brewery, coffee shop and an event center on Marshall Street in northeast Minneapolis. During Christmas, it was unfortunately a community for thieves.
A grocery store worker on Minnesota's North Shore is charged with attempted murder after allegedly stabbing a customer in the neck on Saturday afternoon while in the midst of a mental health crisis.
It's a beauty technique that's exploding. Depending on your age, you might not have heard of it. It's called micro-needling.
The clock is ticking to snag a few more gifts and prepare for that holiday trip to visit family. As the pressure builds, so does the stress.
The Minnesota Athletic Trainers Association says of the middle and high schools they know of, only 49% have an athletic trainer providing some level of service.
From 2021 to 2025, Smart Therapy Center submitted claims totaling $31.8 million across all Minnesota Department of Human Services programs, according to that data. But the provider was only approved for a fraction of those payments.
The family of a Minnesota Vikings player who died at training camp from heat exhaustion in 2001 is still fighting to protect others.
Isiah Whitlock Jr. is perhaps best known for his role as state Sen. R. Clayton "Clay" Davis on HBO's "The Wire."
The band announced Perry Bamonte's death on their official website on Friday.
The message, aired on Channel 4 on Christmas Day, reflected on the impact of President Trump's second term in office thus far.
Feeding America's CEO said the organization is "incredibly grateful" for Taylor Swift's large donation.
The singer said an MRI showed a cancerous spot on one of his lungs after he recovered from a lengthy bout of bronchitis.
Macklin Celebrini had a goal and an assist hours after being selected to play for Team Canada at the 2026 Winter Olympics, and the San Jose Sharks beat the Minnesota Wild 4–3 in a shootout.
Fourteen seasons into his career, Minnesota Vikings safety Harrison Smith is still making an impact.
Kendall Coyne Schofield scored her league-leading sixth and seventh goals, Nicole Hensley shined with a 31-save outing, and the Minnesota Frost topped the Toronto Sceptres 5-1 on Tuesday night.
Stefon Diggs, a star wide receiver with the New England Patriots, is facing criminal charges after an incident in Massachusetts earlier this month.
Quarterback Drew Brees and wide receiver Larry Fitzgerald headline the list of modern era finalists for the Pro Football Hall of Fame.
Minnesota Congresswoman Ilhan Omar is calling for answers about the immigration crackdown in the Twin Cities. She is also denouncing the president's attacks on the Somali community and herself. In Talking Points, Esme Murphy shows us how, for Omar, this is a familiar position to be in.
Minnesota Congresswoman Ilhan Omar is calling for clarity about the immigration crackdown in the Twin Cities.
Fear and uncertainty continue in Minnesota's Somali communities as ICE continues its intensified focus on the Twin Cities.
Opposition to ICE actions is widespread among Democratic elected officials throughout the state, though nowhere more than in Minneapolis, home to the state's largest Somali population.
Minnesotans who welcomed a child this year were able to start applying this week to the state's new paid family and medical leave program to take time off in 2026.
On Dec. 9, 1965, "A Charlie Brown Christmas" debuted on CBS, and it became an instant classic. Lee Jenkins' home is proof that the show is still a hit six decades later.
Holiday lights are on full display across the state right now, and just south of the Twin Cities you'll find a Christmas light show that's been around for more than half a century.
The story begins years ago when the city acquired one of the T-38 Talon Thunderbird jets from the Air Force.
The holidays are upon us, and in the town of Kellogg, Minnesota, you'll find a toy store unlike any other.
With the holidays fast approaching, and lutefisk on the menu for many families, one Minnesota town has the distinction of being called the "Lutefisk Capital of the Country."
Have you ever wondered how the actors memorize so many lines? A neurologist says everyone could strengthen their memories by taking cues from actors.
It's a beauty technique that's exploding. Depending on your age, you might not have heard of it. It's called micro-needling.
According to the Smithsonian Magazine and Britannica, eggnog has British roots.
With the time-honored tradition of gift giving comes gift concealing.
The story of "The Wizard of Oz " is 125 years old, yet still reinventing itself in all kinds of forms.
Minnesotans got a great view of the northern lights Tuesday night.
A look at the newest addition to the polar bear population at St. Paul, Minnesota's Como Zoo.
From food shelves to school programs, our team is proud to serve where it matters most.
The Minnesota State Fair has unveiled its new food, drinks and vendors for 2025.
A suspect was taken into custody after an attack on Pearl Street Mall in Boulder on June 1 in which there were 15 people and a dog who were victims. The suspect threw Molotov cocktails that burned some of the victims, who were part of a march for Israeli hostages.
Overnight temps will either be below zero or single digits for the entire state. Light snow on Thursday morning. Meteorologist Lisa Meadows shares when we see warmer temps.
In Minnesota, weather can be all over the place. Here at WCCO, we want to give you what you need to prepare for what's happening next.
We have a cold night ahead with temperatures in the negatives to single digits for the state. We warm up to the teens on Thursday, but it will remain cold until the weekend. Meteorologist Lisa Meadows shares what our weekend will look like and when we might see temperatures back in the 30s.
Another clipper could throw a few more snow showers our way Thursday morning, WCCO meteorologist Adam Del Rosso reports.
Temperatures will be falling all day from the 30s to the single digits for new year's events this evening, WCCO meteorologist Joseph Dames reports.
Overnight temps will either be below zero or single digits for the entire state. Light snow on Thursday morning. Meteorologist Lisa Meadows shares when we see warmer temps.
Fewer Americans are drinking alcohol which has changed New Year's Eve shopping. Some Minnesotans also share their resolutions.
Minnesota's new paid leave program launched on Wednesday.
Advocates and providers are warning that if federal funding is withheld, legitimate day cares in Minnesota won't be able to survive. Advocates and providers are warning that if federal funding is withheld, legitimate day cares in Minnesota won't be able to survive.
We have a cold night ahead with temperatures in the negatives to single digits for the state. We warm up to the teens on Thursday, but it will remain cold until the weekend. Meteorologist Lisa Meadows shares what our weekend will look like and when we might see temperatures back in the 30s.