Philadelphia doctors use gene editing therapy to treat child with rare disease for the first time
The CRISPR gene editing therapy has been used for other diseases like sickle cell, but this is the first time it's been customized for one patient.
Watch CBS News
The CRISPR gene editing therapy has been used for other diseases like sickle cell, but this is the first time it's been customized for one patient.
The first patient to receive a new gene therapy at the Children's Hospital of Philadelphia is now living pain-free for the first time.
A new gene therapy, developed at the Children's Hospital of Philadelphia, has been approved by the FDA and is being used to transform lives.
Authorities said Michael Vahey was intoxicated when he struck Barbara Friedes, who was biking on Spruce Street, in July 2024.
Natalie Dormer stars in "Audrey's Children" as Dr. Audrey Evans, a CHOP doctor who co-founded Ronald McDonald House Charities.
Audrey Evans was the co-founder of the Ronald McDonald House and a pediatric oncologist at Children's Hospital of Philadelphia. Natalie Dormer, who you might recognize from "Game of Thrones" or "Elementary" plays Evans in the new film "Audrey's Children." Stephanie Stahl reports.
A measles case was detected in a person who recently visited multiple Children's Hospital of Philadelphia facilities, health officials said.
Philadelphia health officials are warning that a child who has measles could have exposed other people to the highly contagious virus at two locations in the city.
Ridley High School's R-Thon raises money and awareness for childhood cancer and cardiac research at Children's Hospital of Philadelphia.
Cleats worn by Eagles quarterback Jalen Hurts are being auctioned off to benefit Children's Hospital of Philadelphia through the NFL's "My Cause, My Cleats" program.
The world's smallest heart pump helped save a Children's Hospital of Philadelphia patient's life. Now that it's been FDA-approved for younger children, doctors say it will help even more.
New high-tech help for young heart patients has been approved by the U.S. Food and Drug Administration. Doctors say this will allow them to save more lives, an important milestone as we kick off American Heart Month.
A brain surgeon at Children's Hospital of Philadelphia has a mission to make cheerleading safer with the Stunt Showdown at Haverford College on Dec. 21.
Making cheerleading safer is the mission of a brain surgeon at Children's Hospital of Philadelphia. Stephanie Stahl reports the new competition that has started.
A Florida family who stays at the Ronald McDonald House while their baby boy gets treatment for OEIS complex calls the community they've met family.
Brailey Valenzuela became the fourth patient at CHOP to successfully undergo this type of fetal heart surgery.
The Children's Hospital of Philadelphia has successfully performed a historic fetal surgery to remove a heart tumor, saving the life of a fetus from Tennessee. Stephanie Stahl reports.
"Tabletop for CHOP" is using Dungeons and Dragons and other tabletop games to raise money for Children's Hospital of Philadelphia.
The babies in the NICU at Children's Hospital of Philadelphia won't be home this Halloween but here's hoping they are healthy and happy for next year. In the meantime, CHOP is still getting the little ones in the holiday spirit.
A group of Philadelphia middle schoolers got an inside look at anesthesiology from local doctors.
CHOP has now performed 32 conjoined twin separations, the most of any hospital in North America.
A Philadelphia family is reunited as conjoined twins are now home after being successfully separated and spending a year at Children's Hospital of Philadelphia. Stephanie Stahl.
Thousands of people are taking over the Benjamin Franklin Parkway in Philadelphia for the annual CHOP Parkway Run and Walk, which raises money to help children fight cancer. This year's goal is to raise $2 million for pediatric cancer research.
With the Sweet Dream Project, Ayana Banks helps transform regular hospital rooms at CHOP into patients' dream rooms.
There's new hope for people with sickle cell disease which affects mainly African Americans. It's gene therapy research at Children's Hospital of Philadelphia that's being called a game changer.
A teenager is in critical condition after a driver hit him on Cottman Avenue Monday afternoon, Philadelphia police say.
An 18-year-old Bethlehem man who was shot at a McDonald's in Allentown has died from his injuries days later, the Lehigh County Coroner's Office said Monday.
A water rescue is underway to find a missing person in Ocean City, New Jersey, Monday night, the Coast Guard said.
Scientists are buzzing about Triantha x novacaesariensis, a newly identified plant found in New Jersey's Pine Barrens.
Life is back to normal for 21-year-old Gianna Parrillo-Shennard, whose life was saved by Jefferson Health's mobile stroke unit.
A water rescue is underway to find a missing person in Ocean City, New Jersey, Monday night, the Coast Guard said.
Philadelphia hit 96 degrees on Monday, breaking the previous high of 94 degrees set on May 18, 1962.
A teenager is in critical condition after a driver hit him on Cottman Avenue Monday afternoon, Philadelphia police say.
An 18-year-old Bethlehem man who was shot at a McDonald's in Allentown has died from his injuries days later, the Lehigh County Coroner's Office said Monday.
The historic Mother African Union Church in Wilmington, Delaware, was destroyed in a fire early Sunday morning.
A teenager is in critical condition after a driver hit him on Cottman Avenue Monday afternoon, Philadelphia police say.
An 18-year-old Bethlehem man who was shot at a McDonald's in Allentown has died from his injuries days later, the Lehigh County Coroner's Office said Monday.
Life is back to normal for 21-year-old Gianna Parrillo-Shennard, whose life was saved by Jefferson Health's mobile stroke unit.
A ceremony at John Janney's gravesite paid tribute to a beloved pen pal who touched the lives of soldiers during World War II.
SEPTA on Monday announced its plans to get fans to and from six World Cup matches in Philadelphia and the fan festival at Lemon Hill.
A water rescue is underway to find a missing person in Ocean City, New Jersey, Monday night, the Coast Guard said.
Scientists are buzzing about Triantha x novacaesariensis, a newly identified plant found in New Jersey's Pine Barrens.
Research conducted by one of New Jersey's largest credit unions found a trip down the Jersey Shore is going to cost 11% more this year on average.
Thousands of people across the country came together Saturday to remember the lives of Johnny and Matthew Gaudreau.
The PrideFest parade Saturday will cross state lines, starting in Lambertville and ending in New Hope, where a full festival celebrates the reason for the season.
The historic Mother African Union Church in Wilmington, Delaware, was destroyed in a fire early Sunday morning.
A Delaware man is in custody after he barricaded himself and started a fire inside a Wawa store on Limestone Road, police say.
A New Castle County, Delaware, refinery is starting repairs that could increase its sulfur dioxide emissions levels past permitted limits.
At 108 years old, Susan Young Browne still exercises, drives and visits the Dover, Delaware, senior center she's been a member of for more than 50 years.
Delaware State University students are taking off from Chandelle Airport in Dover as they work to become future Army aviators.
Life is back to normal for 21-year-old Gianna Parrillo-Shennard, whose life was saved by Jefferson Health's mobile stroke unit.
At least 80 deaths have been reported in a new Ebola disease outbreak in Congo and Uganda, authorities said.
NAMI Montgomery County is hosting a mental health awareness and fundraising walk for the organization's free mental health programs.
The head of the World Health Organization says "our work is not over" to contain hantavirus after evacuations from a cruise ship hit by a deadly outbreak of the illness.
Doctors in New Jersey say an illness known as CHS that affects cannabis users is on the rise.
The 2026 PGA Championship at Aronimink Golf Club is a huge boost for Pottstown, Pennsylvania-based Lessen the Loads.
Bars and restaurants in Newtown Square are gearing up for an influx of customers as the 2026 PGA Championship is here.
If you dine out in Philadelphia during the 2026 FIFA World Cup events, you could end up paying more.
Bimbo Bakeries USA employs over 20,000 people and has been headquartered in Horsham, Pennsylvania, for the past 17 years.
Photos by HughE Dillon
SEPTA on Monday announced its plans to get fans to and from six World Cup matches in Philadelphia and the fan festival at Lemon Hill.
A Delaware woman died in a multi-vehicle crash on I-95 in South Philadelphia Tuesday night while her 4-year-old daughter was in the backseat, state police said.
A serious crash in Hainesport, New Jersey, forced Route 38 to close Thursday night.
The ramp from Front Street to northbound I-95 and the ramp from southbound I-95 to Front Street will reopen the afternoon of May 8 until the morning of May 11.
Breeze Airways launched its first flights out of Atlantic City International Airport just days after Spirit Airlines shut down suddenly.
SEPTA on Monday announced its plans to get fans to and from six World Cup matches in Philadelphia and the fan festival at Lemon Hill.
On Monday, May 18, the merchandise tent at Aronimink Golf Club is open to the public for one day of last-minute shopping, where all remaining items are 50% off.
The 2026 PGA Championship at Aronimink Golf Club brought roughly 200,000 golf fans to Newtown Square, Delaware County.
Rory McIlroy's frustrating final round at the PGA Championship boiled over with an angry exchange with a fan after a "U-S-A!" shout from the gallery at Aronimink Golf Club.
Sunday's win at Aronimink Golf Club in Newtown Square, Pennsylvania, is only his second PGA tour victory, after winning the 2024 Wyndham Championship.
Uzo Aduba and Darren Criss announced the 2026 Tony nominees for select categories on "CBS Mornings" on Tuesday.
If you dine out in Philadelphia during the 2026 FIFA World Cup events, you could end up paying more.
Call Your Mother, a Washington D.C. based bagel and deli chain, now has the keys to Metropolitan's Rittenhouse Square location.
The Philadelphia Museum of Art is embracing a statue it once kept at arm's length.
The "Dog Days Are Over" for the Flyers, but their return to the playoffs comes at the cost of the Florence + the Machine concert.
Ukee Washington reports.
Natasha Brown reports.
Natasha Brown reports.
Natasha Brown reports.
Ukee Washington reports.
Middle school students in Philadelphia got the opportunity to do hands-on learning during the school district's five-day career and technical camp.
With her Girl Talk mentoring program, one Philadelphia teen turned her camp days into a safe space to discuss social issues young girls face every day.
Recent high school graduate Sylvain Farrell says his temporary position at a local clinic is the pathway to a full-time career.
A Philadelphia student won an award from NFL Films for his documentary on bringing back sports teams at his Kensington school.
A group of East Norriton eighth graders took what started as an Earth Day project and made a whole initiative.
Bill Kelly has the latest NEXT Weather forecast for the Philadelphia region Monday night as the Delaware Valley deals with brutally hot conditions.
A newly identified plant discovered in the Pine Barrens of New Jersey is found only in that area, scientists say. Temple University Professor Sasha Eisenman and Russell Juelg, a senior land steward with the New Jersey Conservation Foundation, took CBS News Philadelphia to check it out.
SEPTA on Monday announced its plans for the six World Cup matches in Philadelphia and the fan festival at Lemon Hill.
Police say a man was shot and killed after forcing his way into a home in Northeast Philadelphia. It's unclear if anyone will face charges.
Democratic voters in nearly half of Philadelphia on Tuesday will choose who they want to run to replace retiring Rep. Dwight Evans. Tax attorney Shaun Griffith, state Rep. Chris Rabb, Dr. Ala Stanford and state Sen. Sharif Street are all vying for their party's nod in the race.