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The treatment targets ALS like no other medication on the market.
Two people are in custody after officers found a child and around 20 animals living in poor conditions in Beaver County.
Autism Awareness Month is shining a light on so many goals, including inclusive workforce environments.
Thousands of Native American remains in Ohio could finally be laid to rest under a provision that has cleared the state's House of Representatives.
Businesses and residents want to show survivors and their families their support.
But is there really any better city than Pittsburgh to host the draft, home of the Steelers?
They are Pittsburgh's five jewels -- the city's major parks -- thousands of acres of forests, providing unique access to nature in an urban environment.
Multiple sources confirm Larry Scirotto will be named as the mayor's choice to lead the Pittsburgh Bureau of Police.
The University of Pittsburgh revealed on Thursday what its new athletic facility will look like.
Today is Take Your Kid to Work Day, and we thought we'd get the kids' take on it.
Coming up on Talk Pittsburgh (4/27)
Host Heather Abraham is talking with Lindsey Gurk, a social media influencer, wife, mom and founder of Get Your Pink Back, about motherhood, her creativity with her videos and more!
Host Heather Abraham is sitting down with artist Camerin "Camo" Nesbit. They're talking about his shoe art to his giant mural under the Fort Duquesne Bridge that got the attention of actor and Pittsburgh native Billy Porter!
Allegheny County unveiled the line-up for its free Summer Concert Series and the schedules for Movies in the Parks and Park in the Park.
A water main break sent water shooting up into the air in Ross Township on Thursday afternoon.
Pittsburgh police are continuing their investigation after one person was killed and another was critically injured in an overnight shooting in Pittsburgh's Homewood North neighborhood. KDKA-TV's Megan Shinn has the latest details.
We got to reveal the Flounder Four in our PTL Talk Pittsburgh Fish Fry Bracket!
The one and only Lee Terbosic visited us today to show us a mind-blowing magic trick, and chat about the upcoming season at Liberty Magic.
Chef Crystal Baldwin was in the PTL kitchen showing us a recipe that will steal the show on Easter Sunday. This segment is sponsored by Giant Eagle.
We played a new game of What's It Worth with Dr. Lori!
Schools are already making plans for Tuesday, issuing delays and closures in anticipation of temperatures that will feel like sub-zero.
Police said a man used a knife to slash an Israeli flag outside a home in the city's Mexican War Streets neighborhood.
Penn State's women's team is hosting Robert Morris and the men's team is hosting Michigan State.
Looking for something you saw on KDKA-TV News? Find links and information about the topics and news stories from our newscasts.
Looking overseas, there is wide opposition to the idea of taking Greenland by force.
Mr. Trump previously threatened to impose tariffs against countries that do not support his plans to acquire the territory.
Pennsylvania's two sitting senators, Republican Dave McCormick and Democrat John Fetterman, told CBS News they do not support a U.S. military takeover of Greenland.
The lawmakers posted a video in November that told military service members that they "must refuse illegal orders."
Five congressional Democrats say they have received inquiries from the DOJ after they appeared in a video urging members of the military not to follow "illegal orders" — a move the lawmakers allege is political intimidation.
A Brookline couple says Kia wrongly denied a warranty claim after their car's engine failed at 80,000 miles.
Scams targeting utility customers are on the rise in Pennsylvania, the attorney general says.
A handful of Pittsburgh-area Value City Furniture stores are going out of business after their parent company filed for bankruptcy.
It has been five years since the home improvement retailer Menards bought a large parcel of land off Route 30 in Westmoreland County.
If you get a ticket in the city of Pittsburgh, there could be a higher chance that instead of getting it on your car windshield, you're getting it in the mail.
Another blast of winter is knocking on our door. It’s about to be cold, so the couch or movie theater is officially calling our names, and maybe an electric blanket, too!
PTL's etiquette expert, Liz Aquino, is here to share the rules we’re ready to say goodbye to in 2026.
We’re a few weeks into the new year, and if your resolutions are still hanging on, but your patience in the kitchen is not, Chef Doug Heilman is here with an easy, light recipe that delivers big flavor without the fuss.
Just a few days ago, champions were crowned at the Pennsylvania Farm Show, and while some winners walked away with trophies, one took home bragging rights that you can sip!
Over the last few years, we’ve watched CBS News anchors from around the country say yes to the unknown in the CBS series “Never Too Late.” Now, Pittsburgh Today Live is throwing its hat, or should we say saw, into the ring.
A Brookline couple says Kia wrongly denied a warranty claim after their car's engine failed at 80,000 miles.
Some drivers in Pittsburgh are ignoring road closure signs in the South Side Flats, leaving residents exasperated.
A Westmoreland County taxidermist is under investigation by the Pennsylvania State Police.
Stray voltage from a nearby streetlight shocked Montana Mitchell and her dog, leaving the dog immobile.
Twin boys have been seen selling lemonade for long hours several times a week on street corners throughout Pittsburgh and the suburbs.
The yearly tradition marks the start of months of training for Pittsburgh Marathon participants.
Firefighters have a 62% higher risk of cancer, and this week, the New Castle Central Fire Station hosted pre-screenings.
Once the holidays are over, we often find ourselves in a funk, so how can we find ways to boost our mood?
A major expansion in women's health care is taking shape in Washington County.
Flu cases keep increasing, but at least one Pittsburgh-area emergency room doctor says not everyone needs to visit him.
Penn State's women's team is hosting Robert Morris and the men's team is hosting Michigan State.
Western Pennsylvania has historically been a hotbed for producing talent that succeeds in the NFL.
A program that had played in a grand total of 13 bowl games in the 130-some years before coach Curt Cignetti arrived in 2024 went on a historic run en route to a 16-0 season and a national title.
Brett Kulak broke a second-period tie with his first goal of the season, and the Pittsburgh Penguins beat the Seattle Kraken 6-3.
The Pittsburgh Steelers are searching for a new head coach for the first time in nearly 20 years after Mike Tomlin stepped down last week.
Pittsburgh Mayor Corey O'Connor on Tuesday announced a new initiative aimed at revitalizing neighborhood business districts across the city.
A handful of Pittsburgh-area Value City Furniture stores are going out of business after their parent company filed for bankruptcy.
It has been five years since the home improvement retailer Menards bought a large parcel of land off Route 30 in Westmoreland County.
The Macy's location at the Pittsburgh Mills Mall will be among the several closures.
With the Steelers hosting their first playoff game with fans in the building since 2018, a lot of revenue is expected to be made in the city.
Scott Adams, the cartoonist who created the "Dilbert" comic strip, has died at the age of 68, his first ex-wife revealed on Tuesday.
"The Pitt" won big at the Golden Globes on Sunday night.
The 2026 Golden Globes honored the standouts in both film and television from last year. See the full list of winners and nominees.
Here is everything you need to know about how to watch and stream the 2026 Golden Globes.
Bob Weir wrote or co-wrote and sang lead vocals on Grateful Dead classics including "Sugar Magnolia," "One More Saturday Night" and "Mexicali Blues."
Western Pennsylvania is bracing for a bitter blast, with the windchill expected to make temperatures feel below zero.
KDKA-TV's Bob Pompeani and 93.7 The Fan's Andrew Fillipponi discuss the sports topics of the day.
Stay on top of local weather with First Alert Meteorologist Trey Fulbright's forecast!
This week's edition of Intersections with Mamie Bah.
Here's how some Pittsburghers spent Martin Luther King Jr. Day giving back.
Mike Tomlin stepped down as head coach of the Pittsburgh Steelers after 19 seasons with the team.
Pitt's regular season has ended with an 8-4 record.
Pitt's five-game winning streak came to an end with a 37-15 loss to Notre Dame.
Mason Heintschel set a new Pitt freshman single-game passing record in the Pitt win at Acrisure Stadium.
The 44th annual KDKA-TV Turkey Fund will help our neighbors in need have a nice meal for Thanksgiving.