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Not only did the 49ers give up big plays on defense and make costly penalties, the Colts swarmed Colin Kaepernick at every chance and their secondary didn't let the 49ers find anything easy down field.
The San Francisco 49ers were embarrassed for the second week in a row, this time at home in a 27-7 loss to the Indianapolis Colts. "It looked like the fifth and sixth quarter of the Seattle game (last week)," John Madden told the KCBS Radio morning crew.
The defense fought hard, but in the end could not hold up. With no help from the offensive side of the ball, the defense was fighting a losing battle, and the result was another resounding loss. This time though, its to a team, that San Francisco figured to beat. While there is reason to be concerned, the 49ers will be alright, and still on track for their 2013 goals.
Andrew Luck threw for 164 yards and ran for a 6-yard touchdown while facing college coach Jim Harbaugh for the first time, as the Indianapolis Colts beat the 49ers on Sunday.
Emotions aside for players and coaches with both the San Francisco 49ers and Indianapolis Colts, here are five things to watch for Sunday when the two teams face off for the first time since 2010 on Sunday at Candlestick Park at 1:15 p.m. on KPIX 5.
Jim Harbaugh spent the better part of two seasons building gameplans tailored to the strengths of Andrew Luck, who more often than not executed his coach's schemes.
San Jose police say San Francisco 49ers linebacker Aldon Smith has been arrested on suspicion of driving under the influence.
San Francisco will be breaking in a new starting nose tackle against the Colts, has yet to gain clearance for starting rookie safety Eric Reid and has three other key starters who either missed practice or were limited this week with injuries.
Family pride, bragging rights, even control of the dinner-table conversation. It's all part of a high-stakes poker game in the first-ever head-to-head matchup between 49ers tight end Vernon Davis and Colts cornerback Vontae Davis.
The scoreboard is not the only place where the 49ers were beat up this past weekend. After a relatively injury free start to the season, there are several players who now fill up the injury report, but the news is not all bad. Their opponent has two very significant injuries, and this game will not be nearly as physical as the war that was the game against Seattle.
Coming off an embarrassing loss to the Seattle Seahawks Sunday night, the San Francisco 49ers face the Indianapolis Colts at Candlestick Sunday afternoon. "You don't have a lot of time to pout," John Madden told the KCBS Radio morning crew.
The San Francisco 49ers play the Indianapolis Colts at Candlestick Sunday in a game featuring a former Stanford coach, Jim Harbaugh, and his star college quarterback, Andrew Luck. "Andrew Luck and that Colt offense, they can play," John Madden told the KCBS Radio morning crew.
Trent Richardson will now get a crash course on the Colts' offense and is likely to play this weekend at San Francisco.
No matter that opponents are stacking extra defenders next to the line of scrimmage. The San Francisco 49ers are determined to run the football successfully, a key element of their offense that has been missing through the first two weeks of the season.
In two games, the Seahawks' swarming defense has surrendered only 10 points, shutting down Carolina and San Francisco. They've made Cam Newton and Colin Kaepernick look confused, created game-changing turnovers and shown just how much fun it is making the game miserable for others.
Attorneys for San Francisco 49ers linebacker Aldon Smith and former Niners tight end Delanie Walker have filed a response to a civil lawsuit filed by a Northern California man who says he was shot during a party at Smith's house.
They will be reunited as opponents Sunday, finding themselves in the strange position of game-planning against each other in Week 3 while trying to bounce back from tough losses.
When Vernon Davis and Jim Harbaugh eye the Colts sideline this Sunday, they will each look a little differently at a player looking back at them. There are two members of the opposition that have close ties to the two, and should make for some interesting football come Sunday.
San Francisco 49ers nosetackle Ian Williams was officially placed on injured reserve Tuesday with a broken left ankle. The 49ers also signed fullback Owen Marecic to a one-year contact on Tuesday.
"If you do a helmet-to-helmet, you probably aren't going to get suspended," John Madden told the KCBS Radio morning crew.
The San Francisco 49ers have committed 23 penalties in their first two games for 206 yards, 12 of those for 121 yards against the Seattle Seahawks this past Sunday. They were flagged for two personal fouls and an unsportsmanlike conduct penalty in the fourth quarter.
It looks as though EA Sports manufactured the "eyebrow-shaving" bet that was supposedly setup between quarterbacks Russell Wilson and Colin Kaepernick.
San Francisco welcomes second year sensation Andrew Luck to Candlestick in this Week 3 match up. After leading the Colts to the playoffs as a rookie, Luck is back in his second year to show that he is the real deal. He has weapons around him on offense and a respectable defense, but there is no secret that he is the heart and soul of this team, and they key to their success week in and week out.
The NFC West champions sustained several injuries during Sunday night's 29-3 road defeat at the hands of division rival Seattle, including the expected season-ending ankle injury for nose tackle Ian Williams.
The Seattle Seahawks humbled the San Francisco 49ers in Seattle Sunday night, winning 29-3. "(Seattle is) a legitimate tough team, with a legitimate defense," John Madden told the KCBS Radio morning crew.
A fast-moving wildfire in Mendocino County grew to 841 acres and was 5% contained Saturday night after prompting evacuation orders.
Jake Cronenworth singled in Xander Bogaerts with two outs in the ninth inning and the San Diego Padres beat the San Francisco Giants 6-5 for their seventh win in eight games.
An investigation is underway after a man was found dead Saturday morning at a Caltrain station in San Francisco, police said.
Thousands of people converged on the small town of Pacifica on Saturday morning to witness an event that has become an annual phenomenon: dog surfing.
Several people were killed in a shooting Saturday afternoon at an In-N-Out restaurant in Twin Falls, Idaho, local authorities said.
A fast-moving wildfire in Mendocino County grew to 841 acres and was 5% contained Saturday night after prompting evacuation orders.
An investigation is underway after a man was found dead Saturday morning at a Caltrain station in San Francisco, police said.
Thousands of people converged on the small town of Pacifica on Saturday morning to witness an event that has become an annual phenomenon: dog surfing.
Several people were killed in a shooting Saturday afternoon at an In-N-Out restaurant in Twin Falls, Idaho, local authorities said.
In a quiet neighborhood in Oakland, a backyard was abuzz with young people answering an urgent call to action.
An investigation is underway after a man was found dead Saturday morning at a Caltrain station in San Francisco, police said.
Thousands of people converged on the small town of Pacifica on Saturday morning to witness an event that has become an annual phenomenon: dog surfing.
The goal is not to build traditional low-income housing, but to create high-quality homes that middle-income earners can afford, the Bay Area-based architect said.
The jackhammers echoing through San Francisco's Portsmouth Square this week may sound like noise to most people, but to skateboarders, it's the sound of history being torn down.
San Gregorio State Beach is now roughly twice its size after expanding into the formerly private ranch, San Gregorio Ranch.
In a quiet neighborhood in Oakland, a backyard was abuzz with young people answering an urgent call to action.
An investigation is underway after a woman was shot and killed Friday morning near the Oakland Adult & Career Education Center, officials said.
A man who was convicted in a series of attacks targeting elderly victims in Oakland's Chinatown during the COVID-19 pandemic has been charged in connection with a series of new attacks, prosecutors said.
An East Bay man has been arrested on suspicion of attempted murder after he allegedly shot and robbed his ex-girlfriend outside a Berkeley home last month, while his mother was also arrested for being an alleged accessory, police said.
The city has decided to take on a $2.5 million project to grind down or slice more than 15,000 defects across the city. Most are caused by tree roots pushing the concrete sidewalk out of place.
A 16-year-old California lifeguard who rescued a 10-year-old child from powerful waves during a daring rescue caught on video has spoken out about the harrowing experience.
A South Bay summer camp counselor who was previously arrested for alleged child sexual assaults was arrested again after a third alleged victim came forward, authorities said.
A jury on California's Central Coast has convicted a barber for sexually assaulting clients at his shop, prosecutors said.
A fire burning in eastern Santa Clara County was spreading on Monday after jumping a containment line.
The College Football Players Association has announced that Stanford has become the first team to organize a player-led chapter.
Smoke blanketed the Bay Area Friday, as firefighters continued to battle a wildfire near Salt Point State Park in Sonoma County.
As the SMART train line plans stations at both Healdsburg and Cloverdale, the town of Geyserville, located in the middle, is saying, why not us?
Nicholas Cunfermann disappeared from Novato on Aug. 24, 1986. He was 32 years old.
A fire was burning vegetation near homes in a Mill Valley neighborhood, authorities said Monday.
Invasive Aedes aegeypti mosquitoes, known for transmitting yellow fever and other diseases, have been found in the community of Vacaville, officials said.
Jake Cronenworth singled in Xander Bogaerts with two outs in the ninth inning and the San Diego Padres beat the San Francisco Giants 6-5 for their seventh win in eight games.
San Francisco 49ers receiver Ricky Pearsall will have season-ending surgery on his injured right knee in the latest setback for the 2024 first-round pick.
Jase Bowen hit his first major league homer, Ty France drove in three runs and three San Diego Padres pitchers combined on a two-hitter in a 7-0 victory over the San Francisco Giants.
Romo was arrested in Wisconsin last week, accused of operating a vehicle while intoxicated.
Rookie Daniel Susac hit a two-run home run and had three RBIs, and Robbie Ray pitched six impressive innings to win his seventh straight decision and lead the San Francisco Giants to a 4-1 victory over the San Diego Padres on Thursday night.
A Pleasant Hill man has been arrested in connection with a stabbing in San Francisco after police used surveillance cameras and a drone to track his movements and recover what investigators believe was the weapon used in the attack.
A man who was convicted in a series of attacks targeting elderly victims in Oakland's Chinatown during the COVID-19 pandemic has been charged in connection with a series of new attacks, prosecutors said.
Nearly sixteen years after a San Francisco man was found fatally stabbed inside his apartment, police are seeking information in solving the cold case.
An East Bay man has been arrested on suspicion of attempted murder after he allegedly shot and robbed his ex-girlfriend outside a Berkeley home last month, while his mother was also arrested for being an alleged accessory, police said.
A South Bay summer camp counselor who was previously arrested for alleged child sexual assaults was arrested again after a third alleged victim came forward, authorities said.
The families of four children who died by suicide allege that using social media led to depression, anxiety and other mental health problems.
Anthropic's artificial intelligence model Claude "gained unauthorized access" to three outside organizations on three separate occasions during testing.
OpenAI CEO Sam Altman and other AI leaders say they support pacing the rapid advancement of AI's capabilities.
Three major U.S. airlines have quietly changed their policies to ban humanoid and animal-like robots from their flights.
Schools in three states will be equipped with drones this coming academic year that aim to find and deter active shooters within seconds.
Soaring health insurance premiums are forcing some small business owners to make difficult decisions about employee coverage, staffing and their future.
The case accuses OpenAI of practicing medicine without a license and failing to safeguard users seeking health advice.
A generic version of the allergy medication Zyrtec is under recall across the U.S. over cross-contamination concerns.
Taylor Farms said none of its branded salads or kits contain the iceberg lettuce associated with the outbreak.
A Monterey County company is now at the center of a nationwide cyclosporiasis outbreak. The Washington Post is reporting that lettuce from Taylor Farms, a company headquartered in Salinas, may have supplied contaminated lettuce to Taco Bell.
California Gov. Gavin Newsom's office has released tax returns showing he and his wife made between $1.7 million and $2 million annually from 2022 through 2024.
The Department of Justice in June issued a legal opinion saying states aren't required to provide services that help people with disabilities remain in their homes.
The Trump administration on Thursday reiterated its view that China's alleged efforts to collect millions of American voter registration files constituted election interference.
Sen. Aisha Wahab said the state findings reveal the county missed key warning signs before Sophia Mason's 2022 death, and that similar failures persist today.
San Francisco Mayor Daniel Lurie spent his Wednesday morning touting three ballot initiatives. The most controversial of the three would raise the threshold of signatures that citizens need to gather to qualify for the ballot.
Berlin police did not identify the suspect, who is still at large, by name but said that he was already known to police and is from Berlin.
LGBTQ+ communities have significantly higher rates of unemployment than the general population. Kelsi Thorud reports on how the City of Oakland is empowering LGBTQ+ job seekers during Pride Month.
The fallout over the opposition by a handful of San Francisco Giants players against the team's Pride Night celebrations has prompted an investigation of Major League Baseball by the Trump administration.
Major League Baseball has warned players about writing on their uniforms after San Francisco starter Landen Roupp and two other pitchers added Bible verses to their Pride Night caps on Friday night.
Many LGBTQ+ Pride events across the country have had to scale back or even cancel due to political and financial reasons. San Francisco was on the brink. Kara St. Cyr reports.
A lawsuit alleges that a drive storing a $45 million spy film starring Nicolas Cage was "stolen right off a Netflix desk."
Four women say Hollywood star Jared Leto committed sexual crimes against them when they were teenagers, in interviews with the BBC.
Carly Simon, the singer known for 1970s hits like "You're So Vain," announced she has Parkinson's disease and also was treated for basal cell carcinoma.
Bay Area rapper Mistah F.A.B. was arrested in Oakland after police said he was in possession of thousands of dollars in illegal fireworks.
Paramount Skydance on Friday said it would delay the deal until as late as June 2027.
Ever since the COVID-19 pandemic, the Oakland Unified School District has seen an alarming spike in the number of unhoused students in the school system who deal with a host of challenges far beyond what most children face.
Meteorologist and CBS News Bay Area's resident pilot Lt. Jessica Burch got a treat during Fleet Week, taking to the skies with one of the Blue Angels.
A Bay Area man discovered his devastating loss left him with a new opportunity to rethink how he lives -- follow his journey in virtual reality, 360-degree video.
A groundbreaking medical study involving the UCSF Medical Center has shown some colorectal cancer patients can safely skip radiation treatment and enjoy a potentially higher quality of life.
Every day, San Francisco bar pilot Captain Zach Kellerman goes through what might just be the world's most dangerous commute.
A fast-moving wildfire in Mendocino County grew to 841 acres and was 5% contained Saturday night after prompting evacuation orders.
with Darren Peck.
John Ramos reports.
The university has voluntarily come up with a plan to preserve the pipevine and replant it once the construction is finished.
Kenny Choi reports.
In 2025, KPIX is moving to a new community service award: the CBS News Bay Area Icon Award. Submit nominations for an outstanding community hero at kpix.com/icon.
It's the most wonderful time of the year for a South Bay woman who has played Mrs. Claus for more than 40 years for the children of North San Jose's Alviso District.
For residents of the Oakland Hills, the prospect of another wildfire always remains a concern. This week's Jefferson Awards winner has made it his mission to make the hills and other high-risk areas safer.
In East Palo Alto -- where state education numbers show more than nine in ten public school students are low income and more than half are English learners -- many are finding hope and connection at the Boys & Girls Clubs of the Peninsula.
This week's Jefferson Award winner is Army veteran who continues to live a life of service into his 80s, by feeding hundreds of San Francisco families a week.
A Bay Area man who overcame tremendous obstacles to excel in school has made it his mission to gear up other students for success in the classroom and in life.
For Students Rising Above scholar Josh Collins it took moving across the country to realize the value of his Bay Area family.
Samir Hooker had to grow up fast after his stepfather was shot dead 12 years ago. Now he is watching over his mom and sister while attending UC Berkeley.
It's hard enough to graduate from one of the most prestigious schools in the country when you're the first in your family to go to college. Imagine doing that while you're also trying to protect your parents from being deported?
Some students who are the first in their families to go to college face the challenge of balancing a rigorous academic load while still working to help support their family back home.