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San Francisco will be breaking in a new starting nose tackle against the Colts, has yet to gain clearance for starting rookie safety Eric Reid and has three other key starters who either missed practice or were limited this week with injuries.
Family pride, bragging rights, even control of the dinner-table conversation. It's all part of a high-stakes poker game in the first-ever head-to-head matchup between 49ers tight end Vernon Davis and Colts cornerback Vontae Davis.
The scoreboard is not the only place where the 49ers were beat up this past weekend. After a relatively injury free start to the season, there are several players who now fill up the injury report, but the news is not all bad. Their opponent has two very significant injuries, and this game will not be nearly as physical as the war that was the game against Seattle.
Coming off an embarrassing loss to the Seattle Seahawks Sunday night, the San Francisco 49ers face the Indianapolis Colts at Candlestick Sunday afternoon. "You don't have a lot of time to pout," John Madden told the KCBS Radio morning crew.
The San Francisco 49ers play the Indianapolis Colts at Candlestick Sunday in a game featuring a former Stanford coach, Jim Harbaugh, and his star college quarterback, Andrew Luck. "Andrew Luck and that Colt offense, they can play," John Madden told the KCBS Radio morning crew.
Trent Richardson will now get a crash course on the Colts' offense and is likely to play this weekend at San Francisco.
No matter that opponents are stacking extra defenders next to the line of scrimmage. The San Francisco 49ers are determined to run the football successfully, a key element of their offense that has been missing through the first two weeks of the season.
In two games, the Seahawks' swarming defense has surrendered only 10 points, shutting down Carolina and San Francisco. They've made Cam Newton and Colin Kaepernick look confused, created game-changing turnovers and shown just how much fun it is making the game miserable for others.
Attorneys for San Francisco 49ers linebacker Aldon Smith and former Niners tight end Delanie Walker have filed a response to a civil lawsuit filed by a Northern California man who says he was shot during a party at Smith's house.
They will be reunited as opponents Sunday, finding themselves in the strange position of game-planning against each other in Week 3 while trying to bounce back from tough losses.
When Vernon Davis and Jim Harbaugh eye the Colts sideline this Sunday, they will each look a little differently at a player looking back at them. There are two members of the opposition that have close ties to the two, and should make for some interesting football come Sunday.
San Francisco 49ers nosetackle Ian Williams was officially placed on injured reserve Tuesday with a broken left ankle. The 49ers also signed fullback Owen Marecic to a one-year contact on Tuesday.
"If you do a helmet-to-helmet, you probably aren't going to get suspended," John Madden told the KCBS Radio morning crew.
The San Francisco 49ers have committed 23 penalties in their first two games for 206 yards, 12 of those for 121 yards against the Seattle Seahawks this past Sunday. They were flagged for two personal fouls and an unsportsmanlike conduct penalty in the fourth quarter.
It looks as though EA Sports manufactured the "eyebrow-shaving" bet that was supposedly setup between quarterbacks Russell Wilson and Colin Kaepernick.
San Francisco welcomes second year sensation Andrew Luck to Candlestick in this Week 3 match up. After leading the Colts to the playoffs as a rookie, Luck is back in his second year to show that he is the real deal. He has weapons around him on offense and a respectable defense, but there is no secret that he is the heart and soul of this team, and they key to their success week in and week out.
The NFC West champions sustained several injuries during Sunday night's 29-3 road defeat at the hands of division rival Seattle, including the expected season-ending ankle injury for nose tackle Ian Williams.
The Seattle Seahawks humbled the San Francisco 49ers in Seattle Sunday night, winning 29-3. "(Seattle is) a legitimate tough team, with a legitimate defense," John Madden told the KCBS Radio morning crew.
The Seahawks were left celebrating after another convincing victory over the 49ers, this time a 29-3 rout on Sunday night. It was an addendum to the 42-13 blowout the Seahawks served on San Francisco last December, but this victory means more.
The 49ers and Seahawks met Sunday night, and for the second straight meeting, the Seattle defense was the difference. This game featured the two top dogs of the NFC West, and the Seahawks sent a message not only to the defending division winner, but one to the entire NFL.
Seattle flustered Colin Kaepernick into his worst passing game as a starter and the Seahawks dominated the San Francisco 49ers in a 29-3 win Sunday night.
Colin Kaepernick and Russell Wilson are both looking to build on the best statistical performances of their respective careers Sunday night, when the 49ers visit the Seahawks in a meeting of bitter NFC West rivals.
Week 2 may seem too early for this much hype and anticipation, but the Seahawks and 49ers understand the importance of Sunday evening's NFC West showdown.
Surprises were the order of the NFL's opening weekend, and they present some intriguing possibilities for Week 2.
Former NFL great Steve Young will be one of the keynote speakers at a three-day conference in Salt Lake City exploring how the Mormon faith is dealing with gays and lesbians.
A shelter-in-place order has been issued for a Berkeley neighborhood Monday morning following the discovery of hazardous materials inside a home, officials said.
In a full-page ad in the Wall Street Journal, Ye, the artist formerly known as Kanye West, revealed that the right frontal lobe of his brain was injured in a car accident 25 years ago.
UNAC/UHCP said about 31,000 nurses and health care workers are expected to join the picket lines across California.
Service on the Capitol Corridor rail service between the Bay Area and Sacramento will be reduced for the next several weeks, as the agency seeks to address ongoing mechanical problems that have led to disruptions.
Class-action lawsuit alleged that Google's voice assistant illegally recorded and shared private conversations with advertisers.
A shelter-in-place order has been issued for a Berkeley neighborhood Monday morning following the discovery of hazardous materials inside a home, officials said.
In a full-page ad in the Wall Street Journal, Ye, the artist formerly known as Kanye West, revealed that the right frontal lobe of his brain was injured in a car accident 25 years ago.
UNAC/UHCP said about 31,000 nurses and health care workers are expected to join the picket lines across California.
Service on the Capitol Corridor rail service between the Bay Area and Sacramento will be reduced for the next several weeks, as the agency seeks to address ongoing mechanical problems that have led to disruptions.
Class-action lawsuit alleged that Google's voice assistant illegally recorded and shared private conversations with advertisers.
There are strong upper-level winds rotating around the North Pole that normally keep all cold air contained, but in the winter, the winds weaken, and storms are able to send blasts of cold air directly from the Arctic south into the United States.
In San Jose, more than a hundred people filled San Jose's Mexican Heritage Plaza, chanting, holding up signs, and getting honks of support from the community.
The NBA game between the Minnesota Timberwolves and Golden State Warriors has been postponed following another fatal shooting by federal immigration officers in Minneapolis.
At the Clift Royal Sonesta Hotel, history is not only preserved but also shared through a new speaker series aimed at bringing San Francisco's past to life.
San Francisco's North Beach is home to wonderful Italian food and pastries. It attracts locals and tourists to the area to check out world-famous pizza, but that has caused somewhat of a problem.
A shelter-in-place order has been issued for a Berkeley neighborhood Monday morning following the discovery of hazardous materials inside a home, officials said.
The long-awaited Henry J. Kaiser Center for the Arts has officially reopened in Oakland, marking a major milestone for the city's cultural scene after two decades of closure.
Police in Antioch released additional details into the suspicious death of a person found lying on a roadway early Friday, saying the victim died in a hit-and-run collision.
At the end of this school year, all high school sports coaches and their assistants will be fired, with an option to reapply for their old jobs. The district says it's a new Human Resources policy, but to the coaches and team supporters, it feels like an insult.
With a new California law that lifts restrictions on the types of businesses to lease from Jack London Square, many Oakland business owners hope that new doors of opportunity could open for them.
A man has died following a hit-and-run collision in San Jose Sunday night, police said.
In San Jose, more than a hundred people filled San Jose's Mexican Heritage Plaza, chanting, holding up signs, and getting honks of support from the community.
Step inside the Seymour Marine Research Center at the University of California at Santa Cruz and be prepared to be "swallowed up" by a whale of a tale.
The Monterey County District Attorney's Office released preliminary information and body camera footage of a fatal shooting by police in Marina on Sunday, saying the man killed by officers was armed with a loaded handgun.
An arsonist is on the loose in San Jose, and investigators are looking to see if he may be responsible for burning seven cars at five different locations.
Hundreds of demonstrators gathered in Marin County to protest against ICE and Border Patrol agents following the killing of Alex Pretti on Saturday.
Health officials in Napa County confirmed Wednesday that a child has been diagnosed with measles in the county's first case in nearly 15 years.
Audrey Hitchcock owns Ramini Mozzarella, a line of authentic cheeses made from the milk of water buffaloes.
The Vallejo Police Department said it will receive additional patrol support from Solano County sheriff's deputies through the end of 2026, as the department deals with staffing shortages.
The county says the levee was structurally damaged by the large tidal pressure, sustaining an estimated $2.6 million in damage.
The Seahawks and the Patriots previously met in the Super Bowl back in 2015, when a last-second goal line interception by Malcolm Butler sealed the win for New England.
Stephen Curry scored 26 points to lead the Golden State Warriors past Minnesota 111-85 in the fifth straight loss for the Timberwolves and their longest skid in more than three years.
The NBA game between the Minnesota Timberwolves and Golden State Warriors has been postponed following another fatal shooting by federal immigration officers in Minneapolis.
One-time NFL MVP and longtime San Francisco 49ers quarterback John Brodie has died at the age of 90.
Kevin Johnson died from "blunt head trauma and stab wounds" at a homeless encampment, the Los Angeles County Medical Examiner said.
A man has died following a hit-and-run collision in San Jose Sunday night, police said.
Police in Stockton released the results of a preliminary investigation into a deadly collision involving the city manager last week, saying he was not at fault.
Police in Antioch released additional details into the suspicious death of a person found lying on a roadway early Friday, saying the victim died in a hit-and-run collision.
More than a decade after an Antioch woman was killed, her husband has been charged with her murder, prosecutors said.
San Francisco Mayor Daniel Lurie has teamed up with a state lawmaker in seeking a new law that would toughen penalties on sideshows across California.
Class-action lawsuit alleged that Google's voice assistant illegally recorded and shared private conversations with advertisers.
As the European Union announces an investigation, the Grok chatbot tells CBS News, "Yes, tools like me should face meaningful regulation."
Microsoft services were down for thousands of users, according to tracking service Downdetector.
The billionaire CEO of Tesla and SpaceX, in his first appearance at Davos, said Tesla could start selling its Optimus robots next year.
BART riders will be able to book short Uber rides to and from stations through the agency's app, under a partnership announced Tuesday.
Health officials in Napa County confirmed Wednesday that a child has been diagnosed with measles in the county's first case in nearly 15 years.
Over the years, Dr. Rachel Forer has found plenty of ways to take the sting out of going to the dentist. But no matter how hard she tried, fear had a way of creeping in.
Officials in San Mateo County are the latest in the Bay Area to warn residents to not forage for wild mushrooms, amid a rise in mushroom poisonings that have led to illnesses and even deaths.
The Bay Area's Spare the Air alert has been extended to at least Saturday as a high-pressure system is expected to hang around and impact air quality.
Kaiser Permanente has reached a lawsuit settlement over alleged patient data breaches involving Kaiser websites and mobile applications, with members eligible to receive a payment from a $46 million settlement fund, the health care giant announced.
"When we gaslight and contradict what the public can plainly see with their own eyes, we lose all credibility," one DHS official said.
Police in Stockton released the results of a preliminary investigation into a deadly collision involving the city manager last week, saying he was not at fault.
Beaches along the San Mateo County coast are a favorite visiting spot for Bay Area residents. But one beach in Daly City has had much of its access cut off by a man who claims to own the property above and has erected a chain link fence to keep people out.
Hundreds of demonstrators gathered in Marin County to protest against ICE and Border Patrol agents following the killing of Alex Pretti on Saturday.
Minnesota's secretary of state rejected a request from Attorney General Pam Bondi for federal access state voter rolls and welfare data, as tensions flare in Minneapolis after a man was shot and killed by immigration agents.
The billionaire and philanthropist MacKenzie Scott donated $45 million to The Trevor Project, a nonprofit focused on suicide prevention and advocacy for LGBTQ young people.
Oasis nightclub announced plans to close six months ago. New Year's Eve was slated for the final performance. A last-minute, multi-million dollar donation turned the final curtain call into an encore performance.
A 16-year FBI employee has filed a lawsuit alleging he was fired last month because he had a Pride flag displayed near his desk.
A group of transgender members of the U.S. Air Force and Space Force forced to leave active duty under the Trump administration's policies say their benefits were revoked in a rare move.
California state Sen. Scott Wiener of San Francisco announced Wednesday that he is running for Nancy Pelosi's congressional seat next year.
In a full-page ad in the Wall Street Journal, Ye, the artist formerly known as Kanye West, revealed that the right frontal lobe of his brain was injured in a car accident 25 years ago.
The long-awaited Henry J. Kaiser Center for the Arts has officially reopened in Oakland, marking a major milestone for the city's cultural scene after two decades of closure.
The nominees for the 98th annual Academy Awards were announced Thursday morning, and though "One Battle After Another," "Marty Supreme," "Frankenstein" and "Hamnet" were all nominated for plenty, it was "Sinners" that broke through with a record-smashing 16 nominations.
The 2026 Songwriters Hall of Fame inductees were revealed on "CBS Mornings" on Wednesday. See the full list.
The two-story H Mart will be at Pacific Commons Shopping Center in Fremont, and construction is planned for late 2026. In addition to its grocery selections, it will have a food hall, with a variety of fast-casual eateries, restaurants, a bar and entertainment offerings.
Ever since the COVID-19 pandemic, the Oakland Unified School District has seen an alarming spike in the number of unhoused students in the school system who deal with a host of challenges far beyond what most children face.
Meteorologist and CBS News Bay Area's resident pilot Lt. Jessica Burch got a treat during Fleet Week, taking to the skies with one of the Blue Angels.
A Bay Area man discovered his devastating loss left him with a new opportunity to rethink how he lives -- follow his journey in virtual reality, 360-degree video.
A groundbreaking medical study involving the UCSF Medical Center has shown some colorectal cancer patients can safely skip radiation treatment and enjoy a potentially higher quality of life.
Every day, San Francisco bar pilot Captain Zach Kellerman goes through what might just be the world's most dangerous commute.
More than a hundred people gathered in San Francisco’s Sutro Heights Park Sunday night for a candlelight vigil for Alex Pretti, who was shot and killed by federal agents in Minneapolis. Amanda Hari reports.
One beach in Daly City has had much of its access cut off by a man who claims to own the property above and has erected a chain link fence to keep people out. John Ramos reports.
Hundreds of demonstrators gathered in Marin County to protest against ICE and Border Patrol agents following the killing of Alex Pretti, an incident that has sparked outrage nationwide and prompted renewed demonstrations in the Bay Area. Da Lin reports.
Expect the dry trend to continue into Monday. On Tuesday, the possibility of showers return. Darren Peck has the forecast.
Two decades after it closed, the historic Henry J. Kaiser Center for the Arts in Oakland has reopened following a $100 million renovation. Da Lin reports.
In 2025, KPIX is moving to a new community service award: the CBS News Bay Area Icon Award. Submit nominations for an outstanding community hero at kpix.com/icon.
It's the most wonderful time of the year for a South Bay woman who has played Mrs. Claus for more than 40 years for the children of North San Jose's Alviso District.
For residents of the Oakland Hills, the prospect of another wildfire always remains a concern. This week's Jefferson Awards winner has made it his mission to make the hills and other high-risk areas safer.
In East Palo Alto -- where state education numbers show more than nine in ten public school students are low income and more than half are English learners -- many are finding hope and connection at the Boys & Girls Clubs of the Peninsula.
This week's Jefferson Award winner is Army veteran who continues to live a life of service into his 80s, by feeding hundreds of San Francisco families a week.
A Bay Area man who overcame tremendous obstacles to excel in school has made it his mission to gear up other students for success in the classroom and in life.
For Students Rising Above scholar Josh Collins it took moving across the country to realize the value of his Bay Area family.
Samir Hooker had to grow up fast after his stepfather was shot dead 12 years ago. Now he is watching over his mom and sister while attending UC Berkeley.
It's hard enough to graduate from one of the most prestigious schools in the country when you're the first in your family to go to college. Imagine doing that while you're also trying to protect your parents from being deported?
Some students who are the first in their families to go to college face the challenge of balancing a rigorous academic load while still working to help support their family back home.