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The Buffalo Bills head into Sunday's game against the 49ers as underdogs. Buffalo had a rough end to last year and has had an up-and-down start to this year. For a team that has had problems with turnovers and no real way to move the ball other then on the ground, the Bills will have quite a challenge to beat San Francisco.
The news this week around 49er camp is the naming of Patrick WIllis as NFC Defensive Player of the Week. However, he has had to share the headlines with Brandon Jacobs, who has announced that he is ready to get back on the field.
The 49ers will have to remain humble as they try to improve on the success that they had last year. To avoid a similar let down to the performance they had against Minnesota Vikings, the team will have to stay humble and motivated. To help in their motivation is their new weight room, so the Bills will face a team that certainly hit the weights in preparation for them.
The 49ers jumped up a spot to No. 3 in The NFL power rankings after their 34-0 demolition of the New York Jets on Sunday.
Colin Keapernick made his presence felt in last week's win over the New York Jets. He size and speed put him in the same conversation with Cam Newton and Tim Tebow, but he is still far from earning a starting role in this league. He is on the right team with the right coach and will have a chance to show what he is made of eventually.
San Francisco responded after last weeks last with a 34-0 win over the New York Jets. The team did not play great, but dominated the Jets the whole day and showed that they are the team with a back up quarterback who can make a difference.
Frank Gore, Kendall Hunter and backup quarterback Colin Kaepernick -- on a wildcat-style option -- all ran for scores as the 49ers beat the New York Jets 34-0 on Sunday.
Here's some information that can make the Candlestick parking experience almost as effortless as a Steve Young-to-Jerry Rice pass.
The injury report for the 49ers and Jets had the usual precautionary listings, but the name that stood out is Darrelle Revis. The Jet star is out of the season and both teams will attack the game differently with him out of the line up.
The match up between the New York Jets and San Francisco 49ers will be a game featuring teams with identical records who can't afford to lose the game. The Jets just lost their best player in Darrelle Revis and will playing short handed on defense. The big question entering the game is what impact if any Tim Tebow will have.
The San Francisco 49ers have multiple reasons to get fired up to play in New York this week.
After failing to do anything offensively last week, there will be pressure on the offense to put some points on the board, and that will have to come by air. Smith and his receivers will need to get up to speed if they want to avoid another loss by only scoring 13 points like last week.
Two days after a controversial call cost the Green Bay Packers a win, the NFL and the referees' union are reportedly nearing an end to a lockout that put replacement officials on the field since the start of the season.
Coach Jim Harbaugh wants the San Francisco 49ers to get focused, avoid obstacles and get back to winning.
After suffering their first defeat last week in Minnesota, San Francisco needs to bounce back against the Jets in New York. To ease the challenge of back-to-back Eastern road games, the 49ers elected to stay out East rather than travel back to San Francisco. The 49ers were in a similar situation last year and it worked out fine.
Tony Vitello walked up the dugout stairs to meet with reporters about 15 minutes later than expected because of a team meeting that went longer than planned.
The bushes that surrounded global superstar Bad Bunny during his record-breaking Super Bowl halftime performance at Levi's Stadium were indeed people in costume, and three Bay Area friends participated together after answering a vague casting call.
The Detroit Tigers announced Tuesday that they signed Justin Verlander, a 42-year-old free agent, to a one-year, $13 million deal.
San Francisco 49ers defensive lineman Keion White was shot and injured early Monday morning in San Francisco, the team confirmed.
Puerto Rican superstar Bad Bunny, born Benito Antonio Martínez Ocasio, is one of the most-streamed artists on the planet.
Google and Pepsi were among the best ads of the Big Game, while Coinbase and ai.com got failing grades, according to one ranking.
When a fan ran onto the field during the Super Bowl, Patriots player Kyle Williams ran to track him down.
The 31-year-old Puerto Rican artist Bad Bunny took the stage on Sunday dressed in all white, donning a jersey with his last name, Ocasio, and the number 64.
The Seattle Seahawks defeated the New England Patriots Sunday to win the 2026 Super Bowl.
The Cupertino City Council voted 3-2 in favor of a unique affordable housing project that will also reserve units for those with intellectual and developmental disabilities (IDD).
Groundbreaking research in the Monterey Bay National Marine Sanctuary is revealing that communication among whales is far more complex and sophisticated than previously believed.
About 300 pounds of processed marijuana was discovered by San Leandro police, leading to an arrest on Wednesday, authorities said.
Police in San Francisco announced that a teenage suspect has been arrested in connection with a mass shooting in the Richmond District near Ocean Beach late last year.
Americans, not foreign exporters, shouldered nearly the costs from the Trump administration's tariffs last year, according to the New York Fed.
Police in San Francisco announced that a teenage suspect has been arrested in connection with a mass shooting in the Richmond District near Ocean Beach late last year.
Schools in the San Francisco Unified School District will remain closed for a fifth straight day on Friday, as the teachers' strike continues without a labor deal.
Parents held a virtual roundtable to talk about the ongoing strike in the San Francisco Unified School District.
The California Highway Patrol has issued a Feather Alert for a missing woman last seen in San Francisco in January.
San Francisco schools will be closed for a fourth day on Thursday, said Laura Dudnick, San Francisco Unified School District director of communications.
About 300 pounds of processed marijuana was discovered by San Leandro police, leading to an arrest on Wednesday, authorities said.
A former member of the San Leandro City Council pled guilty in a corruption case that has ties to former Oakland Mayor Sheng Thao, federal prosecutors said.
The Alameda County Sheriff's Office said they received a call from a person claiming to have a firearm around 3:20 Monday morning. When deputies arrived, they say a person exited the home on Selborne Drive and presented an immediate threat to deputies. Two deputies shot at him, and he died from his injuries.
Some prospective tenants said they are still without housing and have been cut off from all help because they are officially listed in the county's computer as "permanently housed" at the Phoenix Apartments.
The legacy of the Black Panther Party, founded in Oakland in 1966 to protect the Black community while demanding freedom and justice, lives on through an award-winning walking tour.
The Cupertino City Council voted 3-2 in favor of a unique affordable housing project that will also reserve units for those with intellectual and developmental disabilities (IDD).
A San Jose shop owner has discovered that for the unhoused, a bicycle isn't just a reliable way of getting around; it can be a lifeline for a fresh start.
An assistant principal at a San Jose middle school was among a group of people arrested during a police operation targeting adults seeking minors online to engage in sexual activity, authorities announced on Wednesday.
Authorities on the Central Coast have recovered a body after a car plunged several hundred feet off Highway 1 in Big Sur Tuesday afternoon.
Authorities in Monterey County have arrested a man on suspicion of attempted murder after he allegedly stabbed a woman while driving on Highway 101 in Salinas over the weekend.
A Sonoma County man has been arrested on multiple weapons charges after police seized more than 150 firearms from two homes as part of an investigation into the illegal manufacturing of guns.
One of the suggestions is the complete renovation of the Canal District shoreline, removing about 550 existing homes and raising the land high enough to safely redevelop on top of it. It is projected to cost nearly $2 billion.
A bank employee was among three people arrested in a series of armed home invasion robberies in Marin County of people who had withdrawn large amounts of cash, authorities said.
A man who was arrested on child sexual abuse charges in Illinois is facing additional charges in the San Francisco Bay Area in connection with the alleged sexual assault of a child, police said.
Four suspects remain at large and two were arrested after an armed robbery at a Petaluma jewelry store on Saturday, police said.
Tony Vitello walked up the dugout stairs to meet with reporters about 15 minutes later than expected because of a team meeting that went longer than planned.
The bushes that surrounded global superstar Bad Bunny during his record-breaking Super Bowl halftime performance at Levi's Stadium were indeed people in costume, and three Bay Area friends participated together after answering a vague casting call.
The Detroit Tigers announced Tuesday that they signed Justin Verlander, a 42-year-old free agent, to a one-year, $13 million deal.
San Francisco 49ers defensive lineman Keion White was shot and injured early Monday morning in San Francisco, the team confirmed.
Puerto Rican superstar Bad Bunny, born Benito Antonio Martínez Ocasio, is one of the most-streamed artists on the planet.
About 300 pounds of processed marijuana was discovered by San Leandro police, leading to an arrest on Wednesday, authorities said.
Police in San Francisco announced that a teenage suspect has been arrested in connection with a mass shooting in the Richmond District near Ocean Beach late last year.
A former member of the San Leandro City Council pled guilty in a corruption case that has ties to former Oakland Mayor Sheng Thao, federal prosecutors said.
Border czar Tom Homan announced Thursday that Operation Metro Surge in Minnesota is concluding, with a drawdown of federal immigration officers set to occur over the course of next week.
The California Highway Patrol has issued a Feather Alert for a missing woman last seen in San Francisco in January.
The Federal Trade Commission sent a letter to Tim Cook one day after President Trump circulated a report raising questions about Apple News' practices.
The family believes the outcome of the trial can lead to significant changes within the social media industry and help other families become even more aware of what they say are deadly devices in the hands of children.
The social media platform changed its privacy policy last month, inviting users to allow it to track their specific location.
Instagram's parent company Meta and Google's YouTube dispute claims that their platforms deliberately addict and harm children.
ChatGPT will clearly distinguish between ads and answers to user prompts on the AI platform, according to OpenAI.
Health officials in the East Bay said a man has died from consuming toxic wild mushrooms, amid an ongoing spike in mushroom-related poisonings throughout California.
Health officials in Napa County confirmed Wednesday that a child has been diagnosed with measles in the county's first case in nearly 15 years.
Over the years, Dr. Rachel Forer has found plenty of ways to take the sting out of going to the dentist. But no matter how hard she tried, fear had a way of creeping in.
Officials in San Mateo County are the latest in the Bay Area to warn residents to not forage for wild mushrooms, amid a rise in mushroom poisonings that have led to illnesses and even deaths.
The Bay Area's Spare the Air alert has been extended to at least Saturday as a high-pressure system is expected to hang around and impact air quality.
A former member of the San Leandro City Council pled guilty in a corruption case that has ties to former Oakland Mayor Sheng Thao, federal prosecutors said.
Border czar Tom Homan announced Thursday that Operation Metro Surge in Minnesota is concluding, with a drawdown of federal immigration officers set to occur over the course of next week.
Vilma Palacios is one of thousands who have given up their immigration cases and voluntarily left the U.S. after being detained. More detainees are opting for voluntary departure than ever before, a CBS News analysis found.
With so many candidates and no clear frontrunner in California's governor's race, two Republicans now lead in the polls in this heavily Democratic state, raising the question: Could the primary election lead to a Republican-versus-Republican runoff?
Pentagon officials had undertaken planning to use military technology near Fort Bliss, in El Paso, to practice downing drones.
After more than two years of renovations, the historic Castro Theatre is back open for business.
A large Pride flag has been removed from the Stonewall National Monument in Greenwich Village. The National Park Service said it did so under guidance from the federal government.
The billionaire and philanthropist MacKenzie Scott donated $45 million to The Trevor Project, a nonprofit focused on suicide prevention and advocacy for LGBTQ young people.
Oasis nightclub announced plans to close six months ago. New Year's Eve was slated for the final performance. A last-minute, multi-million dollar donation turned the final curtain call into an encore performance.
A 16-year FBI employee has filed a lawsuit alleging he was fired last month because he had a Pride flag displayed near his desk.
"Dawson's Creek" and "Varsity Blues" star James Van Der Beek has died at 48 years old.
After more than two years of renovations, the historic Castro Theatre is back open for business.
The bushes that surrounded global superstar Bad Bunny during his record-breaking Super Bowl halftime performance at Levi's Stadium were indeed people in costume, and three Bay Area friends participated together after answering a vague casting call.
The show unfolded as a visual journey through Puerto Rico's history, culture and identity, reaching an estimated 135 million viewers worldwide.
Puerto Rican superstar Bad Bunny, born Benito Antonio Martínez Ocasio, is one of the most-streamed artists on the planet.
Ever since the COVID-19 pandemic, the Oakland Unified School District has seen an alarming spike in the number of unhoused students in the school system who deal with a host of challenges far beyond what most children face.
Meteorologist and CBS News Bay Area's resident pilot Lt. Jessica Burch got a treat during Fleet Week, taking to the skies with one of the Blue Angels.
A Bay Area man discovered his devastating loss left him with a new opportunity to rethink how he lives -- follow his journey in virtual reality, 360-degree video.
A groundbreaking medical study involving the UCSF Medical Center has shown some colorectal cancer patients can safely skip radiation treatment and enjoy a potentially higher quality of life.
Every day, San Francisco bar pilot Captain Zach Kellerman goes through what might just be the world's most dangerous commute.
The Cupertino City Council voted 3-2 in favor of a unique affordable housing project that will also reserve units for those with intellectual and developmental disabilities (IDD).
Sooji Nam reports.
Thursday's school board meeting is the last one scheduled before March 12, when a decision is set to be made on the future of multiple elementary schools across San Jose.
During their meeting Thursday, BART’s board of directors looked at a doomsday scenario to see what would happen if the sales tax measure failed.
The Pacifica School Board of Trustees voted to close Ocean Shore and Valley Mar Middle School last year, an effort to close a $3.3 million budget deficit.
In 2025, KPIX is moving to a new community service award: the CBS News Bay Area Icon Award. Submit nominations for an outstanding community hero at kpix.com/icon.
It's the most wonderful time of the year for a South Bay woman who has played Mrs. Claus for more than 40 years for the children of North San Jose's Alviso District.
For residents of the Oakland Hills, the prospect of another wildfire always remains a concern. This week's Jefferson Awards winner has made it his mission to make the hills and other high-risk areas safer.
In East Palo Alto -- where state education numbers show more than nine in ten public school students are low income and more than half are English learners -- many are finding hope and connection at the Boys & Girls Clubs of the Peninsula.
This week's Jefferson Award winner is Army veteran who continues to live a life of service into his 80s, by feeding hundreds of San Francisco families a week.
A Bay Area man who overcame tremendous obstacles to excel in school has made it his mission to gear up other students for success in the classroom and in life.
For Students Rising Above scholar Josh Collins it took moving across the country to realize the value of his Bay Area family.
Samir Hooker had to grow up fast after his stepfather was shot dead 12 years ago. Now he is watching over his mom and sister while attending UC Berkeley.
It's hard enough to graduate from one of the most prestigious schools in the country when you're the first in your family to go to college. Imagine doing that while you're also trying to protect your parents from being deported?
Some students who are the first in their families to go to college face the challenge of balancing a rigorous academic load while still working to help support their family back home.
