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"This is a setback of probably a decade for HIV vaccine research," one scientist said.
A worried Minnesota mother says she hasn't heard from her teenage son in weeks.
Efforts are underway in Lake Elmo to remove dangerous PFAS chemicals from the environment.
Two brothers show the meaning of tenacity and love for the game after being seriously injured during a devastating car accident in 2023.
Loretta Swit played Maj. Margaret Houlihan on the TV series "M*A*S*H."
The U.S. Department of Homeland Security is taking aim at Minnesota and its Twin Cities, alleging the deliberate obstruction of the enforcement of federal immigration laws, and protecting "dangerous criminal aliens from facing consequences."
Minnesota transportation officials say a serious rollover crash involving a semi shut down Interstate 94 at the Lowry Hill Tunnel for hours on Friday.
Taylor Swift announced she owns the masters of her first six studio album in a letter shared on her website.
A Minnesota state trooper returned to the witness stand on Friday to face cross examination from the defense in the trial of Derrick Thompson, the son of a former Minnesota lawmaker charged in a deadly 2023 crash in Minneapolis that killed five young women.
Police in St. Anthony are asking for the public's help in finding a vehicle they say was involved in a hit-and-run that injured two people on Wednesday.
Wildfire smoke from Canada is expected to move over the U.S., and maps and satellite imagery show the large-scale impact of the blazes.
Police in Brooklyn Park, Minnesota, need the public's help to find 20-year-old Precious Urrutia, who went missing on Wednesday.
A family of five managed to escape a house fire overnight Thursday in Brooklyn Center, Minnesota, but their home was destroyed.
The Minnesota Pollution Control Agency has issued a statewide air quality alert, including all tribal nations, that will be in effect through 6 p.m. Monday due to smoke from the raging wildfires in Canada's Manitoba and Saskatchewan provinces.
President Trump announced Friday he'll double steel tariffs from 25% to 50% during a visit at a U.S. Steel mill in the Pittsburgh area.
The U.S. may be at war with Iran, but it's a small stretch of water to the country's south that is at the center of the conflict right now. Iran has been blocking the Strait of Hormuz for weeks, making gas prices surge. The Iranian foreign minister said the regime will reopen the strait during the ceasefire, but experts tell WCCO's Ashley Grams we'll be waiting quite a while to pay less at the pump.
WCCO meteorologist Chris Shaffer says tomorrow will be warmer and windier.
A man who fought to fly his private chopper in cabin country is grounded. A judge sided with the city, ruling he can't use his cabin as a helipad. But as Frankie McLister reports, he's not giving up.
There are dueling ethics complaints filed against Minnesota House members by Republicans and Democrats. As Caroline Cummings reports, each accuses a member of the other party of violating the rules.
The Minneapolis City Council is listening to different opinions about making it legal to have needles, syringes and other drug paraphernalia.
Three Minnesota ice cream shops are in the running for a national title this summer.
The Mall of America in Bloomington is likely the most complicated place in the state to keep cool. WCCO got an exclusive look at the cooling system on the site's roof.
It may not be the first sport you think of, but cheerleading is definitely a sport. There are an estimated 4.5 million participants across 70 countries, with most in the U.S., where the sport originated.
Firefighters are working to put out a blaze at a church in Rosemount, Minnesota, on Monday afternoon.
The Minnesota State Patrol and the Eagan Police Department responded to a report of a road rage incident on northbound Interstate 35E near Deerwood Drive around 5:16 p.m., according to Eagan police.
The southeastern Minnesota community of Wabasha is reeling after a deadly crash on Lake Pepin Saturday night.
We know what the heat does to people and pets, but it also poses a challenge for Minnesota farmers trying to keep their livestock healthy during hot days.
A man is dead after he collided with an SUV while riding an electric bike in Rochester, Minnesota, on Sunday afternoon.
The Boundary Waters Canoe Area Wilderness will close on Tuesday as wildfires burn amid an active heat wave in northern Minnesota.
The U.S. Forest Service closed 225,000 acres of the Boundary Waters Canoe Area Wilderness on Saturday due to multiple wildfires and continued dry conditions.
Two of the decedents were members of the Wabasha Fire Department, the chief confirmed.
A Wisconsin family lost their ten-month-old daughter after she swallowed a water bead. They blame Target and the water bead manufacturer for her death.
Francesca Hong has not backed away from calls to defund and abolish the police, raise taxes on the wealthy, and create a state-owned bank — positions now facing voters in a state Trump has carried twice.
A former Wisconsin judge will soon learn her sentence for felony obstruction for helping an immigrant evade federal officers.
The Wisconsin Supreme Court ruled 5-2 that guardianship records sought by the Wisconsin Voter Alliance to identify ineligible voters are not public records under state law.
The city of St. Paul, Minnesota, is taking a stand and closing encampments amid growing concerns.
Baseball fans might remember the Metrodome's iconic blue seats, and now in Atwater, Minnesota, spectators can once again grab a blue seat and watch a game.
Tucked away in the Midway neighborhood in St. Paul is a community treasure many have come to love and respect.
What started as a small fundraiser following one of Joe's surgeries at Gillette Children's has grown into a community tradition that has raised nearly $100,000 for the hospital.
A trip to the video store was once a weekly ritual, and now one Minnesota movie lover is trying to bring that experience back.
The top prosecutors of Minnesota and Hennepin County say federal investigators are now sharing evidence in connection to the shootings by immigration agents in the state amid Operation Metro Surge earlier this year in Minneapolis, including Renee Good's SUV.
U.S. District Judge Kathleen Williams said President Trump's lawsuit against the IRS had been filed for an "improper purpose."
The top prosecutors of Minnesota and Hennepin County say federal investigators are now sharing evidence in connection to the shootings by immigration agents in the state amid Operation Metro Surge earlier this year in Minneapolis, including Renee Good's SUV.
Increased strikes come as Iran threatens not to hold up its end of the framework for peace if the U.S. doesn't uphold its commitments.
There's less than a month to go before the Aug. 11 primary, and one of the most watched and competitive races is the DFL race for the nomination for U.S. Senate between Lt. Gov. Peggy Flanagan and Rep. Angie Craig.
A Wisconsin family lost their ten-month-old daughter after she swallowed a water bead. They blame Target and the water bead manufacturer for her death.
For many Minnesotans, the road to the Fourth of July starts with a short drive across the St. Croix River to Wisconsin to stock up on fireworks. The kinds of pyrotechnics that can be legally ignited in Minnesota might be surprising.
Insurance experts say hail damage claims that once averaged $10,000–$15,000 now routinely reach $40,000–$60,000, even as many policies have shifted away from full replacement coverage.
Hundreds of workers, employed by Delaware North Company to serve food and drinks, say they are fighting for livable wages and healthcare benefits.
Target is tapping designer and TV personality Isaac Mizrahi for a newly created role as creative director at large as the discounter aims to reclaim its reputation for stylish clothing on a budget.
A man labeled by the Department of Justice as the 78th person charged in the Feeding Our Future fraud scheme has pleaded guilty, according to a court document filed in the U.S. District Court of Minnesota on Monday.
The top prosecutors of Minnesota and Hennepin County say federal investigators are now sharing evidence in connection to the shootings by immigration agents in the state amid Operation Metro Surge earlier this year in Minneapolis, including Renee Good's SUV.
The Minnesota State Patrol and the Eagan Police Department responded to a report of a road rage incident on northbound Interstate 35E near Deerwood Drive around 5:16 p.m., according to Eagan police.
Two people were injured when they jumped from a moving trailer after the pickup truck it was attached to was stolen Saturday morning in Minneapolis.
A judge sentenced a man to 10.5 years in prison in connection with a federal crackdown involving dozens of members of a major gang in Minneapolis.
More than 75,000 Minnesotans have been approved for the state's paid family and medical leave program, which launched at the beginning of the year.
Skip the latest fad diet. The best way to manage your weight might already be sitting on your plate.
Dozens of Twin Cities hospice workers are walking the picket line Monday in a one-day strike after nearly a year of negotiations for an inaugural union contract.
As Mayor Jacob Frey pledges a crackdown at open-air drug markets in Minneapolis, WCCO found brutal honesty about the situation from people who say they actively participate in the illicit trade.
Noah Walden says he didn't notice anything unusual while eating. About three days later, he began experiencing stomach pain that continued to worsen over the next several days.
Three Minnesota ice cream shops are in the running for a national title this summer.
New Zealand actor Sam Neill, known for "Jurassic Park" and "The Piano," died Monday at 78, his family says.
A St. Paul, Minnesota, neighborhood that has struggled to keep businesses might be turning a corner.
It's another action-packed weekend here in Minnesota, featuring hot dogs, book fairs, community celebrations and more.
Bonnie Tyler, the Welsh pop star best known for singing the chart-topping power ballad "Total Eclipse of the Heart" in 1983, has died. She was 75.
Kayla McBride scored a season-high 37 points, rookie Olivia Miles had a career-high 33 and the Minnesota Lynx beat the Phoenix Mercury 104-100 on Monday night for their third straight victory.
It may not be the first sport you think of, but cheerleading is definitely a sport. There are an estimated 4.5 million participants across 70 countries, with most in the U.S., where the sport originated.
Trevor Larnach homered and drove in two runs, Ryan Jeffers added a two-run double and the Minnesota Twins beat the Los Angeles Angels 4-2 Sunday and have won eight of their last nine series heading into the All-Star break.
Royce Lewis hit a two-run homer and sparked the go-ahead rally with a seventh-inning double as the Minnesota Twins beat the Los Angeles Angels 5-3.
Kayla McBride scored 14 of her 25 points in the fourth quarter, Olivia Miles added 23 points after missing two games and the Minnesota Lynx edged the New York Liberty 90-85.
There's less than a month to go before the Aug. 11 primary, and one of the most watched and competitive races is the DFL race for the nomination for U.S. Senate between Lt. Gov. Peggy Flanagan and Rep. Angie Craig.
New campaign finance numbers are expected out later this week in federal races, including Minnesota's U.S. Senate race, where a flood of ads is evidence of a highly competitive race.
Minnesota Republicans head into an August primary shaped by a president who has lost the state three times but still commands outsized loyalty from its conservative base.
Minnesota Republicans head into an August primary shaped by a president who has lost the state three times but still commands outsized loyalty from its conservative base.
Mike Lindell, who leads the Minnesota Republican gubernatorial primary at 27%, is proposing conditional non-resident visas for undocumented immigrants with no criminal record — a position that differs from the Trump administration's approach.
There's a scenic, nearly century-old spot in St. Cloud, Minnesota, where right now you'll find thousands of flowers in bloom.
Baseball fans might remember the Metrodome's iconic blue seats, and now in Atwater, Minnesota, spectators can once again grab a blue seat and watch a game.
It's a lake cruise in the middle of town, and there's more than pelicans on the Pelican Breeze tour in Albert Lea, Minnesota.
Currie, Minnesota, is truly small-town America. The population hovers at just over 200. But on the northern outskirts, you'll happen upon a place with plenty of bells and whistles: End-O-Line Railroad Park and Museum
School's out, summer's here, and if you're heading to the lake on Highway 10, you may just stumble upon hidden treasure.
It's one of Minnesota's rules of the road in which two is better than one. But Jodi from Lakeville emailed WCCO saying a lot of drivers don't seem to care about the law.
Catching a flight with just a carry-on can make travel feel easy. No need to check a bag and all your belongings stay with you. But quite often, that suddenly changes before boarding.
Skip the latest fad diet. The best way to manage your weight might already be sitting on your plate.
There's no doubt your air conditioning unit is working overtime this week as oppressive heat blankets Minnesota.
In every corner of the metro, and across Minnesota, you'll find construction crews ripping up roads and rebuilding bridges. WCCO looks into whether the piles of rubble they create can get a second life.
The Minnesota State Fair has unveiled its new foods for 2026.
A look back at the esteemed personalities who've left us this year, who'd touched us with their innovation, creativity and humanity.
Minnesotans got a great view of the northern lights Tuesday night.
A look at the newest addition to the polar bear population at St. Paul, Minnesota's Como Zoo.
From food shelves to school programs, our team is proud to serve where it matters most.
Dangerous heat will continue across Minnesota for the next few days.
In Minnesota, weather can be all over the place. Here at WCCO, we want to give you what you need to prepare for what's happening next.
Dangerous heat will continue across Minnesota for the next few days.
Soccer teams from 24 states and 13 countries are set to take part in the Target USA Cup in Blaine. But they'll have to face an added opponent — the sweltering sun.
An extreme heat warning is in effect until 9 p.m. Thursday for the majority of Minnesota, according to NEXT Weather meteorologist Chris Shaffer.
Dangerous heat will continue across Minnesota for the next few days.
Hundreds of youth soccer players from all over the world are in Blaine for the USA Cup. Ubah Ali shows how organizers are changing their game plan to account for the heat.
An extreme heat warning is in effect until 9 p.m. Thursday for the majority of Minnesota, according to NEXT Weather meteorologist Chris Shaffer.
It's one of Minnesota's rules of the road in which two is better than one. But Jodi from Lakeville emailed us saying a lot of drivers don't seem to care about the law. In this Good Question, Jeff Wagner explores the rules regarding license plates - and how police enforce them.
A prayer service took place Monday night at a Wabasha church for three people who died after a boat crash at Lake Pepin Saturday night. WCCO's Ashley Grams reports.