Police said it happened at about 10:40 a.m. near the intersection of 128th Avenue and 238th Street.
Police said the bus was traveling southbound when it hit a man riding a motorized bike heading eastbound. First responders pronounced the man dead at the scene. He was not wearing a helmet, police said.
The driver stayed at the scene, but has been pulled out of service as the investigation continues.
MTA officials called the collision a "tragic accident" and are cooperating with police.
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