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The San Francisco 49ers were still basking in the glow of an exhilarating road win against division rival Seattle that extended their perfect start to the season when Christian McCaffrey offered a word of caution.
Brock Purdy and the Niners (4-0) get a chance to reverse that trend when they visit the defending Super Bowl champion Seahawks (3-1) for the first time this season.
The 49ers are the first team in 12 years to allow no sacks through three games as Purdy's elusiveness and strong play from the offense line have frustrated the opposition.
The NFL fined San Francisco 49ers All-Pro fullback Kyle Juszczyk for what it deemed an "offensive" celebration similar to one he had been doing for several years with no issues.
Christian McCaffrey became the fourth-fastest player in the Super Bowl era with 100 career touchdowns, Brock Purdy played a near-perfect game and the San Francisco 49ers overwhelmed the Miami Dolphins 35-13.
San Francisco 49ers coach Kyle Shanahan says defensive tackle Alfred Collins is out for the season after tearing his patellar tendon.
Las Vegas rookie quarterback Fernando Mendoza saw what it was like Thursday night to face a strong NFL pass rush even against a San Francisco defense comprised of reserves.
The San Francisco 49ers held their final practice before their exhibition finale with nearly two dozen injured players missing but remain hopeful that most will be able to return to practice next week before the team departs for Australia for the season opener.
Jacob Cowing returned a punt for an 83-yard touchdown, Eddy Pineiro kicked a pair of field goals and the San Francisco 49ers beat the Los Angeles Chargers 41-17 on Thursday night in a preseason game.
Cam Ward struggled in three drives for Tennessee against San Francisco's backup defense and the Titans went on to beat the 49ers 19-13 in the exhibition opener for both teams.
Head coach Kyle Shanahan will have limited participation at the beginning of the San Francisco 49ers' training camp after he was injured in a crash. The team said his injuries are not life-threatening.
The San Francisco 49ers sat out the first round of the NFL draft, making two trades down after the players they targeted went off the board earlier.
San Darnold's NFL career had hit rock bottom when he arrived in San Francisco in 2023 after failing at two spots to live up to his high draft billing.
The San Francisco 49ers are hiring former Atlanta Falcons head coach Raheem Morris as their new defensive coordinator in hopes of finding a long-term solution to a revolving door at the spot.
San Francisco's star linebacker Fred Warner is out for the 49ers' playoff game against Seattle.
San Francisco 49ers' Trent Williams and Ricky Pearsall missed practice Wednesday, raising doubts about their availability for the wild-card playoff against the Philadelphia Eagles.
The San Francisco 49ers have placed receiver Brandon Aiyuk on the reserve/left squad list, making him ineligible to return from a knee injury this season.
Brock Purdy rushed for a touchdown and passed for another score in the second half, and the San Francisco 49ers spoiled Shedeur Sanders' first home start with a 26-8 victory over the Cleveland Browns.
Quarterback Brock Purdy returns to the starting lineup for the San Francisco 49ers this week after missing six games with a toe injury.
San Francisco 49ers quarterback Brock Purdy is set for an aggressive practice on Wednesday.
The San Francisco 49ers lost another key defensive player for the season when rookie Mykel Williams went down with a knee injury.
San Francisco 49ers defensive lineman Mykel Williams will miss the rest of the season after the first-round pick was diagnosed with torn ligaments in his right knee.
Christian McCaffrey and the San Francisco 49ers hope to get back on track running the ball against the New York Giants and their 30th-ranked rush defense.
C.J. Stroud threw for a season-high 318 yards with two touchdowns and the Texans got off to a quick start and held on for a 26-15 victory.
Four-time All-Pro linebacker Fred Warner will need season-ending surgery after he was sidelined by a severe ankle injury during San Francisco's loss to Tampa Bay.
