The crash closed part of Jerome Avenue all afternoon, CBS2's Natalie Duddridge reported.
Surveillance video shows two vehicles were driving side-by-side on Jerome Avenue around 11:15 a.m. when officials said they collided. One careened into an oncoming commuter bus.
The view from Chopper 2 showed the articulated bus smashed into a support pole beneath the elevated 4 subway line near Woodlawn Station.
Bystanders ran to the scene to help.
"All you heard was, 'Boom, boom,'" one person said.
"We heard the crash. So then when we walked down, we noticed the bus and the car crashed together," said another.
It's unclear exactly how many people were on the bus at the time, but officials said 14 people were treated for a range of mostly minor injuries.
One person was taken to the hospital in critical condition.
The bus driver was also hurt. The front of the bus crumpled when it hit the pillar.
Subway service was unaffected.
The drivers of three vehicles remained on the scene and were interviewed by police.
There was no immediate word on any charges.
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