Brock Purdy throws 4 TD passes, 49ers defeat Cardinals despite injuries

The San Francisco 49ers keep losing key players to injuries and still keep winning, thanks in large part to the play of quarterback Brock Purdy.

• Sep 28

49ers' big win over Cardinals fueled by Purdy, takeaways, key special teams play

Brock Purdy returned to the lineup and the San Francisco 49ers scored their most points in nearly two years.

• Nov 17, 2025

Brock Purdy throws 3 TDs in return from toe injury, 49ers cruise to 41-22 win over sloppy Cardinals

Brock Purdy threw three touchdown passes in his return from a toe injury, Christian McCaffrey had two rushing touchdowns and a receiving score, and the San Francisco 49ers beat the sloppy Arizona Cardinals 41-22.

• Nov 16, 2025

49ers QB Brock Purdy returns to starting lineup after missing 6 games

Quarterback Brock Purdy returns to the starting lineup for the San Francisco 49ers this week after missing six games with a toe injury.

• Nov 13, 2025

49ers' Nick Bosa exits win vs. Cardinals with knee injury, gives thumbs-down to crowd

San Francisco 49ers star Nick Bosa left the win against the Arizona Cardinals with a knee injury.

• Sep 21, 2025

Pineiro's last-second field goal lifts 49ers to thrilling 16-15 win over Cardinals

Eddy Pineiro has kicked a 35-yard field goal to give the San Francisco 49ers a 16-15 win over the Arizona Cardinals.

• Sep 21, 2025

49ers' Brock Purdy "highly unlikely" to start against Cardinals because of toe injury

Quarterback Brock Purdy is highly unlikely to start for the San Francisco 49ers on Sunday because of a toe injury.

• Sep 19, 2025

49ers QB Brock Purdy returns to practice, could play Sunday against Arizona

San Francisco 49ers quarterback Brock Purdy returned to practice on Wednesday after missing a game with a toe injury.

• Sep 17, 2025

49ers lose to Cardinals 47-24 in season finale

Kyler Murray threw for 242 yards and four touchdowns, two to Greg Dortch, and the Arizona Cardinals beat the injury-depleted San Francisco 49ers 47-24.

• Jan 5, 2025

Joshua Dobbs will start the finale at QB for the 49ers in place of the injured Brock Purdy

Joshua Dobbs will start the season finale at quarterback for the San Francisco 49ers with starter Brock Purdy out with an elbow injury.

• Jan 1, 2025

49ers eliminated from NFC playoffs ahead of game against Miami

The defending NFC champion San Francisco 49ers were eliminated from the playoffs before their game at Miami began on Sunday because of victories by Washington and the Los Angeles Rams.

• Dec 23, 2024

49ers fined $100,000 by the NFL after Dre Greenlaw shoved an opponent on the sideline

The San Francisco 49ers were fined $100,000 as punishment for an inactive player getting involved in a sideline scuffle.

• Oct 12, 2024

49ers have little time to dwell on latest collapse with Seahawks looming

The short week means there will be little time spent going over all the mistakes from Sunday, but there were plenty.

• Oct 7, 2024

49ers blow double-digit lead in 24-23 loss to division rival Cardinals

This marked the second time this season that San Francisco (2-3) blew a double-digit lead in the fourth quarter to a division rival, having done it in Week 3 against the Los Angeles Rams.

• Oct 6, 2024

49ers look to keep winning ways going vs. Cardinals; 3 keys to victory

After the 49ers evened their record at 2-2 by beating the Patriots, the next step is to stack wins on top of each other, which the Niners have a chance of doing Sunday against the Arizona Cardinals.

• Oct 5, 2024

Game Day: Purdy and McCaffrey Carry 49ers To 4-0 Start

Matt Lively reports from Levi's Stadium as Christian McCaffrey scores four times, Brock Purdy was nearly perfect and the 49ers beat Arizona 35-16 to improve to 4-0. (10-2-23)

• Oct 2, 2023