A statement from press secretary Josh Earnest said Mr. Obama will speak about "steps our government is taking to fulfill his highest priority: keeping the American people safe."
Mr. Obama will deliver his address at 8 p.m. ET. Scott Pelley will anchor a live CBS News special report. CBSN will stream the address online at cbsnews.com/live.
Earnest said Mr. Obama will give Americans an update on the investigation into Wednesday's shooting that killed 14 people. The FBI announced Friday that it was investigating the rampage in Southern California as "an act of terrorism."
Mr. Obama will also speak about the "broader threat of terrorism," including the nature of the threat and how the president plans to defeat it, Earnest said.
"He will reiterate his firm conviction that ISIL will be destroyed and that the United States must draw upon our values -- our unwavering commitment to justice, equality and freedom -- to prevail over terrorist groups that use violence to advance a destructive ideology," Earnest said, using an acronym for the Islamic State of Iraq and the Levant, a different name for ISIS.
FBI Director James Comey said on Friday that it appears the attackers, Syed Farook and his wife, Tashfeen Malik, were radicalized and potentially inspired by foreign terrorist organizations, but beyond that, much remains unknown, CBS News correspondent Julianna Goldman reports.
Sources told CBS News that right before the rampage Malik, using another name, went on Facebook and pledged her allegiance to ISIS and its leader, Abu Bakr al-Baghdadi.
The extremist group hasn't claimed responsibility for the attack. On Saturday, ISIS released an audio statement referring to the couple as "soldiers of the caliphate."