Watch CBS News
The Niners take on the team with the longest odds to win it all this season as the biggest favorites in Week 2 against the Miami Dolphins in their home opener on Sunday.
San Francisco 49ers rookie receiver De'Zhaun Stribling is expected to miss at least two months after undergoing surgery on his injured left ankle.
Mike Evans, Demarcus Robinson and Deebo Samuel caught touchdown passes from Brock Purdy, and the San Francisco 49ers routed the Los Angeles Rams 27-7 in the first NFL regular-season game in Australia.
The longest road trip in NFL history has brought the San Francisco 49ers and the Los Angeles Rams to Australia's sports capital for a season opener in front of more than 100,000 football-hungry fans packed into the Southern Hemisphere's largest stadium.
San Francisco 49ers coach Kyle Shanahan says defensive tackle Alfred Collins is out for the season after tearing his patellar tendon.
Aaron Donald won't play Week 1, delaying his return to the field after ending his retirement last month.
San Francisco 49ers star pass rusher Nick Bosa is set to play in the season opener against the Los Angeles Rams in his first game action since a tearing a knee ligament last September.
The San Francisco 49ers have arrived in Melbourne for their season-opening NFL game against the Los Angeles Rams at the Melbourne Cricket Ground on Sept. 11.
Las Vegas rookie quarterback Fernando Mendoza saw what it was like Thursday night to face a strong NFL pass rush even against a San Francisco defense comprised of reserves.
In a news release, the NFL said it plans to "elevate" Pro Bowl selections, with no replacement selections.
The San Francisco 49ers held their final practice before their exhibition finale with nearly two dozen injured players missing but remain hopeful that most will be able to return to practice next week before the team departs for Australia for the season opener.
San Francisco 49ers owner Jed York has pleaded no contest to two misdemeanor charges in Northeast Ohio after being arrested on suspicion of engaging in prostitution over the weekend, authorities said.
The rate is much higher than is seen in the general population. CTE is a brain disease linked to repeated blows to the head.
Jacob Cowing returned a punt for an 83-yard touchdown, Eddy Pineiro kicked a pair of field goals and the San Francisco 49ers beat the Los Angeles Chargers 41-17 on Thursday night in a preseason game.
Cam Ward struggled in three drives for Tennessee against San Francisco's backup defense and the Titans went on to beat the 49ers 19-13 in the exhibition opener for both teams.
The former San Francisco 49ers star running back spoke in a prerecorded video message while he sat on stage wearing his gold jacket at Tom Benson Stadium on Saturday.
Wide receiver Mike Evans missed practice for the San Francisco 49ers because of a strained quadriceps in the latest injury to hit the team's receiver room.
San Francisco 49ers receiver Ricky Pearsall will have season-ending surgery on his injured right knee in the latest setback for the 2024 first-round pick.
San Francisco 49ers receiver Ricky Pearsall has been sidelined by a knee injury and there is no timeline for his return.
The Khosla family ownership group, including Vinod Khosla, has entered into a formal agreement to purchase the defending Super Bowl champion Seattle Seahawks.
The family of former NFL player Doug Martin filed a federal civil rights lawsuit against the City of Oakland, several Oakland police officers, and a paramedic company after his death last year while in police custody.
The family of former NFL star Aldon Smith is donating his brain to the Boston University CTE Center to research the long-term effects of repetitive brain injuries following his sudden death at age 36.
Perhaps the only person around the San Francisco 49ers not worried about the heavy workload All-Pro Christian McCaffrey handled last season is McCaffrey himself.
Nick Bosa is encouraged by the pace of his recovery from another major knee surgery and believes he's on track to return to the field during training camp and start the season on time for the San Francisco 49ers.
Aaron Rodgers says his 22nd season in the NFL will be his last.
The Niners take on the team with the longest odds to win it all this season as the biggest favorites in Week 2 against the Miami Dolphins in their home opener on Sunday.
A San Jose married couple and an employee were charged with running a brothel out of a Cupertino day spa business, prosecutors said on Thursday.
The San Jose Sharks have signed coach Ryan Warsofsky to a multiyear contact extension on the first day of training camp before his third season at the helm.
One person has died after a fishing boat on San Francisco Bay crashed near the Golden Gate Bridge early Thursday morning, officials said.
Meet "Granna," the 82-year-old crossing guard who's been watching over San Francisco schoolkids for 19 years.
The Niners take on the team with the longest odds to win it all this season as the biggest favorites in Week 2 against the Miami Dolphins in their home opener on Sunday.
A San Jose married couple and an employee were charged with running a brothel out of a Cupertino day spa business, prosecutors said on Thursday.
The San Jose Sharks have signed coach Ryan Warsofsky to a multiyear contact extension on the first day of training camp before his third season at the helm.
One person has died after a fishing boat on San Francisco Bay crashed near the Golden Gate Bridge early Thursday morning, officials said.
Meet "Granna," the 82-year-old crossing guard who's been watching over San Francisco schoolkids for 19 years.
One person has died after a fishing boat on San Francisco Bay crashed near the Golden Gate Bridge early Thursday morning, officials said.
Meet "Granna," the 82-year-old crossing guard who's been watching over San Francisco schoolkids for 19 years.
The birds, which resemble tiny penguins, are starving because the water has warmed, increasing the metabolism of predator fish, making them hungrier.
Musicians and management remain divided over pay, with the orchestra rejecting proposed cuts and the Opera citing a $15 million annual deficit.
Moving forward, there will be free health and wellness events at the Presidio, including outdoor yoga and an outdoor wellness installation in 2027 through Sutter Health's partnership with the San Francisco 49ers.
Fire crews in Alameda battled a fire that damaged a vacant building early Thursday morning.
Claudia Atkinson started her business out of her garage in West Oakland and opened her first brick-and-mortar shop in downtown Oakland about three months ago.
A former East Bay financial advisor was sentenced on Wednesday to nine years in federal prison for running a decades-long Ponzi scheme that defrauded investors out of nearly $10 million, authorities said.
The idea of establishing a coal transport base next to the Port of Oakland isn't new, and neither is the fight it caused in West Oakland. But in July, President Trump rekindled the issue when he signed an order to give $75 million for the project.
Before the sun rose Tuesday morning, a sweep of Berkeley's long-established and embattled Harrison encampment began.
A San Jose married couple and an employee were charged with running a brothel out of a Cupertino day spa business, prosecutors said on Thursday.
Firefighters battling major wildfires in California's Big Sur region are continuing to make progress, as authorities lifted evacuation orders for one of the fires Wednesday.
Mayor Matt Mahan said the new data-tracking system, UrbanLogiq, estimates that roughly 3,700 people are still living in the streets. Down from the last internal city count of just over 5,400.
A San Jose police officer was fired after using a personal device to access automated license plate reader data while off-duty, the police chief said.
A judge on Friday granted a preliminary injunction blocking further construction of a U.S. Immigration and Customs Enforcement facility in Santa Clara County near Gilroy.
Four people were arrested days after an assault in downtown Sonoma that left a man dead, authorities said.
A growing number of residents in two Northern California counties have been allowed to return home as firefighters increased containment on the Lucas Fire burning near the Mendocino National Forest.
A masseuse in the North Bay was arrested following the alleged sexual assaults of two customers at a massage parlor over the weekend, authorities said.
A shooting in San Rafael injured the alleged gunman who was later tracked down with a police drone, authorities said.
Firefighters in Northern California continued to increase containment on the Lucas Fire burning near the Mendocino National Forest, as evacuations remained in effect Sunday.
The Niners take on the team with the longest odds to win it all this season as the biggest favorites in Week 2 against the Miami Dolphins in their home opener on Sunday.
The San Jose Sharks have signed coach Ryan Warsofsky to a multiyear contact extension on the first day of training camp before his third season at the helm.
San Francisco 49ers rookie receiver De'Zhaun Stribling is expected to miss at least two months after undergoing surgery on his injured left ankle.
Quinn Mathews took a no-hitter into the sixth inning and Alec Burleson had an RBI single to lead the St. Louis Cardinals to a 2-1 victory over the San Francisco Giants.
Manny Machado hit a two-run homer and the San Diego Padres ran their winning streak to seven games with a 6-4 victory over the San Francisco Giants on Sunday night.
A San Jose married couple and an employee were charged with running a brothel out of a Cupertino day spa business, prosecutors said on Thursday.
A former East Bay financial advisor was sentenced on Wednesday to nine years in federal prison for running a decades-long Ponzi scheme that defrauded investors out of nearly $10 million, authorities said.
Four people were arrested days after an assault in downtown Sonoma that left a man dead, authorities said.
A masseuse in the North Bay was arrested following the alleged sexual assaults of two customers at a massage parlor over the weekend, authorities said.
A shooting in San Rafael injured the alleged gunman who was later tracked down with a police drone, authorities said.
About 43,000 people are expected to attend the annual AI and enterprise tech conference hosted by Salesforce which comes amid calls for a slowdown in AI developments.
Top OpenAI executive endorses plan that would require AI companies to submit their technology to third-party reviews to assess their safety.
Sen. Bernie Sanders is one of the most vocal opponents in Congress on rapid AI development, but bipartisan concerns are growing.
Some San Francisco officials are looking to pause the construction of any new data centers that support the exploding AI industry.
AI has fueled a stock boom in recent years. Now, some Wall Street analysts think that epic run is coming to an end.
Officials in the East Bay city of Berkeley have issued a warning to residents and doctors amid a rising number of bats that have tested positive for rabies.
Patients taking the first-of-a-kind pill, called daraxonrasib, lived for a median of 13.2 months compared with 6.7 months for chemotherapy recipients, studies showed.
Moderna and Merck announced study results that reflect a "landmark moment" in treatment for one of the deadliest forms of skin cancer.
Multiple unpermitted street food vendors in Fairfield were cited for violations last week after inspections found them selling food unsafe for public consumption, authorities said.
After weeks of uncertainty, students at Richmond's John F. Kennedy High School will start their classes on schedule after weeks after toxic chemicals were found underneath the campus.
In court documents filed Wednesday by Rep. Joyce Beatty, a witness said he saw a "forklift run into and hit the pillars" of the building.
Mayor Matt Mahan said the new data-tracking system, UrbanLogiq, estimates that roughly 3,700 people are still living in the streets. Down from the last internal city count of just over 5,400.
California firefighters, police officers and other public safety employees rallied at the state Capitol this week, urging Gov. Gavin Newsom to sign legislation that supporters say would allow first responders to retire earlier and improve their retirement benefits.
According to a Government Accountability Office (GAO) report published Tuesday, the use of paid administrative leave increased by 435% from 2023 to 2025.
Qualifying collector cars will gradually become exempt from smog checks beginning Jan. 1, 2028.
California Attorney General Rob Bonta has joined a coalition of 19 attorneys general in supporting a federal lawsuit challenging Idaho's law that bars transgender students from using school restrooms and other sex-separated facilities that align with their gender identity.
Berlin police did not identify the suspect, who is still at large, by name but said that he was already known to police and is from Berlin.
LGBTQ+ communities have significantly higher rates of unemployment than the general population. Kelsi Thorud reports on how the City of Oakland is empowering LGBTQ+ job seekers during Pride Month.
The fallout over the opposition by a handful of San Francisco Giants players against the team's Pride Night celebrations has prompted an investigation of Major League Baseball by the Trump administration.
Major League Baseball has warned players about writing on their uniforms after San Francisco starter Landen Roupp and two other pitchers added Bible verses to their Pride Night caps on Friday night.
The 78th Primetime Emmy Awards celebrated the best in television and streaming from the past year on Monday. See the full list of winners and nominees.
Performer Macklemore is being dropped from Ed Sheeran's Loop tour after making on-stage statements that some found controversial.
Dubbed the "Designer to the Stars," Bob Mackie won nine Emmy Awards, a Tony Award and was nominated for three Oscars.
Season-opening performances of the San Francisco Opera have been canceled, as orchestra musicians announced a strike.
Celine Dion's return to the stage underscored a remarkable comeback after stiff-person syndrome, an incurable condition that causes stiffness and cramps, forced her to cancel shows and cast years of uncertainty over whether she would ever perform again.
Ever since the COVID-19 pandemic, the Oakland Unified School District has seen an alarming spike in the number of unhoused students in the school system who deal with a host of challenges far beyond what most children face.
Meteorologist and CBS News Bay Area's resident pilot Lt. Jessica Burch got a treat during Fleet Week, taking to the skies with one of the Blue Angels.
A Bay Area man discovered his devastating loss left him with a new opportunity to rethink how he lives -- follow his journey in virtual reality, 360-degree video.
A groundbreaking medical study involving the UCSF Medical Center has shown some colorectal cancer patients can safely skip radiation treatment and enjoy a potentially higher quality of life.
Every day, San Francisco bar pilot Captain Zach Kellerman goes through what might just be the world's most dangerous commute.
Meet "Granna," the 82-year-old crossing guard who's been watching over San Francisco schoolchildren for 19 years. Drew Andre reports.
Fire crews in Alameda knocked down a fire that damaged a vacant building early Thursday morning. Drew Andre reports.
On Thursday, expect pleasant conditions throughout the Bay Area, with mostly clear skies and highs in the 60s and 70s. Jessica Burch has the forecast.
Andrea Nakano reports.
Bay Area teachers are using artificial intelligence to enhance what they can do in the classroom and allow them to focus even more on students. Max Darrow reports.
In 2025, KPIX is moving to a new community service award: the CBS News Bay Area Icon Award. Submit nominations for an outstanding community hero at kpix.com/icon.
It's the most wonderful time of the year for a South Bay woman who has played Mrs. Claus for more than 40 years for the children of North San Jose's Alviso District.
For residents of the Oakland Hills, the prospect of another wildfire always remains a concern. This week's Jefferson Awards winner has made it his mission to make the hills and other high-risk areas safer.
In East Palo Alto -- where state education numbers show more than nine in ten public school students are low income and more than half are English learners -- many are finding hope and connection at the Boys & Girls Clubs of the Peninsula.
This week's Jefferson Award winner is Army veteran who continues to live a life of service into his 80s, by feeding hundreds of San Francisco families a week.
A Bay Area man who overcame tremendous obstacles to excel in school has made it his mission to gear up other students for success in the classroom and in life.
For Students Rising Above scholar Josh Collins it took moving across the country to realize the value of his Bay Area family.
Samir Hooker had to grow up fast after his stepfather was shot dead 12 years ago. Now he is watching over his mom and sister while attending UC Berkeley.
It's hard enough to graduate from one of the most prestigious schools in the country when you're the first in your family to go to college. Imagine doing that while you're also trying to protect your parents from being deported?
Some students who are the first in their families to go to college face the challenge of balancing a rigorous academic load while still working to help support their family back home.