While full body scans can take as little as 10 seconds, a full pat-down can take four minutes, reports CBS News correspondent Don Teague. Experts say if only a small percentage participate in the boycott, it could still cause a cascade of delays at dozens of major airports around the country.
The protest, National Opt-Out Day, is scheduled for Wednesday to coincide with the busiest travel day of the year.
"I don't think it would take that much on the busiest day of the year to slow things down," said Gerry Berry, a Florida-based airport security expert. "If I was an airport guy, a screener, a traveler - I'd be concerned."
Not all airports have the machines, which resemble large refrigerators. And not all travelers are selected for scans. But Berry estimated that up to 20 percent of holiday fliers will be asked to use the full-body machines - meaning tens of thousands could be in a position to protest.
The full-body scanners show a traveler's physical contours on a computer in a private room removed from security checkpoints. But critics say they amount to virtual strip searches.
The protest was conceived in early November by Brian Sodergren of Ashburn, Va., who built a one-page website urging people to decline the scans.
Public interest in the protest boomed this week after an Oceanside, Calif., man named John Tyner famously resisted a scan and groin check at the San Diego airport with the words, "If you touch my junk, I'll have you arrested." A cell-phone video of the incident went viral.
Other groups have since taken up Sodergren's cause.
"I had no idea what was being started and just how upset people were," said Sodergren, a health industry employee. "I'm just a guy who put a website up."
The Transportation Security Administration has a new pat-down procedure that includes a security worker running a hand up the inside of passengers' legs and along the cheek of the buttocks, as well as making direct contact with the groin area.
Passenger Thomas Sawyer said his recent pat-down at Detroit's Metro Airport was so aggressive, it spilled the urine bag he's had to carry since cancer surgery. He had to travel in urine-soaked shirt and pants, reports Teague.
"I was just mortified," said Sawyer.
Pat-downs often take up to four minutes, according to the TSA's website, though that could be longer if someone requests it be done in a room out of public view or if an ill-at-ease traveler asks for a full explanation of the procedure beforehand.
Factoring in those time estimates, it would take a total of around 15 minutes to put 100 people through a body scan - but at least 6 hours to pat down the same number of travelers.
The TSA's Chicago spokesman, Jim Fotenos, would not disclose how many travelers are normally selected for scans. He said only "a relatively small percentage" normally need pat-downs.
Fotenos declined to say if the agency was taking precautionary steps ahead of the protest, saying only that passengers can make their experience better "by coming prepared and arriving early."
On Friday, TSA head John Pistole told CBS's "The Early Show" that the close-quarter body inspections are unavoidable in a time of terrorist threats.
Pistole acknowledged the public distaste for more intense security, particularly hand pat-downs, and called it a "challenge" for federal authorities and airport screeners.
Appearing Monday on "The Early Show," Pistole said the TSA is still looking to strike "that balance between the security and privacy," but stressed that improved security measures are needed to protect against possible attacks.
Pistole also addressed the prospect of a Thanksgiving travel boycott of the body screening, saying he hopes protesters "would consider … [that] the vast majority of people just want to get home for the holidays and spend time with their loved ones. … I just feel bad for those people who might be delayed because of lines caused by people who want to protest."
Also Friday, the TSA agreed to allow airline pilots to skip security scanning and pat-downs. According to pilot groups, pilots in uniform on airline business would be allowed to pass security by presenting two photo IDs, one from their company and one from the government, to be checked against a secure flight crew database.
David Castelveter, a spokesman for the Air Transport Association, which represents the airline industry, declined to speculate whether the protest would trigger delays.
"It is impossible to assess how many people will take part, but we would be disappointed if many travelers did participate on one of the busiest days of the year," Castelveter said.
He said airlines always urge customers to show up early during peak holiday travel times and were not suggesting any changes specifically because of the protest.
Delta Air Lines planned to have extra staff in place as it normally does during a holiday travel period. Spokeswoman Susan Elliott said the company was not taking any extra precautions in case of widespread protests.
Southwest Airlines Paul Flaningan said only that his company was "aware of what is being talked about, and we are in constant communication with the TSA."
He said Southwest was not bringing in extra workers specifically because of the threatened protest.
Karen Pride, a spokeswoman for Chicago's Department of Aviation, which oversees O'Hare and Midway airports, would say only that the airports planned to bring in extra workers for the holiday, but she declined to address the potential effect of the protest.
Sodergren sounds much less strident than many critics of screening procedures. And he says he's not trying to cause disarray at airports.
"I have no idea what's going to happen," he said "I don't think it will be chaos. And I have no desire to slow the system down."
But some protesters are aiming to do just that.
Another participating organization called "We Won't Fly" features a blurb at the top of its website that says, "Jam TSA checkpoints by opting out until they remove the porno-scanners."
Organizer James Babb of Eagleville, Pa., agreed many travelers would see the pat-down as equally intrusive or more so. But he's still recommending the pat-down because, he says, it would create more disruption and send a stronger message.
"They won't have the manpower to reach into everyone's crotch," he said.
Passengers cannot opt out of both the scan and the pat-down once they have been selected for the enhanced searches, according to TSA rules. If they then try to evade the measures, they could face an $11,000 fine.
Even if someone in a security line becomes frustrated and decides not to fly, TSA rules require they submit to a scan or pat-down. If people were allowed to walk out, the agency says, would-be terrorists would have an easy escape.
At least some entrepreneurs are offering passengers other forms of protest.
One Las Vegas company is selling designer rubber patches to cover body parts that travelers do not want screeners to see. One patch for the crotch area includes text written in fonts associated with Las Vegas billboards that reads, "What Happens Under Here - Stays Here."
And for anyone who wants to express displeasure with pat-downs, Tyner's confrontation has spawned online sales of T-shirts, bumper stickers and even underwear emblazoned with the words, "Don't Touch My Junk!"
Ironically, one person who will not take part directly in Wednesday's protest is its instigator, Brian Sodergren. He said his wife is too uncomfortable with the prospect of either a body scan or a pat-down, so they are driving the several hundred miles to a relative's home.