Among her targets? Amal Clooney, who attended the event in a black Dior gown and long white gloves.
It was the human rights attorney's choice in accessories that caught the ire of Griffin and her "Fashion Police" cohorts.
"I thought it was weird she had those gloves that remind me of, like, a porn scene, where the guy goes home and there's the naughty dishwasher and she only has the gloves," the comedienne said of George Clooney's wife.
Co-host Kelly Osbourne agreed with Griffin's criticism of the gloves. "I don't understand," she said. "The only time I've seen a glove like that was on a veterinarian show."
"I'm fascinated how we're like not supposed to make fun of her because she married to the great George Clooney," Griffin added. "Look: Everybody is on the table, George. Nobody is safe. Nobody gets a pass."
Earlier in the show, Griffin took a moment to pay tribute to Rivers, who died in September after complications from surgery.
"Before I start making more enemies and burning new bridges, I want to thank my good friend," she said of her "Fashion Police" predecessor. "Joan, I know you are watching from heaven, but I am not afraid to bring the hammer down on anyone."