Study: Smoking, Heavy Drinking Linked To Earlier Cancer Onset

ANN ARBOR (CBS Detroit) Lifestyle plays a significant factor in the development of pancreatic cancer, according to a study led by a University of Michigan Health System gastroenterologist that found bad habits can bring earlier onset of pancreatic cancer.

The average age at which pancreatic cancer is found is 72, according to the American Cancer Society -- but in the study published in the American Journal of Gastroenterology, heavy smokers with pancreatic cancer were diagnosed around age 62 and heavy drinkers at age 61 – almost a decade earlier.

Smoking is a strong risk factor for pancreatic cancer and alcohol has been shown to cause oxidative damage to the pancreas, and which sets the stage for the inflammatory pathways that can lead to cancer, researchers said.

In the study heavy smokers were defined as those who had more than a pack per day, and heavy drinking was measured at more than 39 grams a day, or about three average drinks per day.

The findings do not prove the habits caused cancer, only that these habits can lead to developing pancreatic cancer earlier in life.

The study encompassed 811 pancreatic cancer patients from the multicenter, international database Pancreatic Cancer Collaborative Registry.

"As screening programs are developed, an understanding of how personal features influence the age of presentation will be important to optimize the timing of those screenings," says lead study author and gastroenterologist Michelle Anderson, M.D., assistant professor of internal medicine at the University of Michigan Health System.

Detecting pancreatic cancer early is difficult and contributes to the poor survival rates. By the time pancreatic cancer is diagnosed, it is frequently at an advanced stage and has spread to other organs. Currently there are no tests available to easily find it in people who do not have symptoms.

And there were degrees, with beer drinkers presented with pancreatic cancer earlier than those who drank other types of alcohol, such as wine or hard liquor, although when adjusted for the amount of alcohol consumed, the type of alcohol did not affect the age of presentation.

The good news is that the harmful effects of heavy drinking and smoking can be reversed. After 10 years, former smokers and drinkers who quit their habits faced no extra risk of earlier diagnosis.