Watch CBS News
Josh Allen threw for 375 yards and tied a career high with four touchdown passes as the Bills stayed in sole possession of first place in the AFC East with a thoroughly impressive 34-24 victory over the San Francisco 49ers.
After overcoming issues with several injured players, the San Francisco 49ers managed to put together one of the league's top defenses this season thanks in large part to their defensive coordinator Robert Saleh.
49ers coach Kyle Shanahan is concerned about the mental wellbeing of his players, who have left their families for at least three weeks after strict new COVID-19 protocols in Santa Clara County prohibited games and practices for contact sports until at least Dec. 21.
The 49ers have plenty of work to do if they want to make it back to the playoffs this season.
With a surge in coronavirus cases, the information you need to know is coming fast and furious. Here's a roundup of the COVID stories we've published over the last 24 hours.
With COVID cases soaring in Santa Clara County and new restrictions in place, the San Francisco 49ers will head to Arizona Wednesday, relocating all team operations for at least the next three weeks.
Robbie Gould made a 42-yard field goal as time expired, and the 49ers snapped their three-game losing streak with a 23-20 victory over the Rams on Sunday, sweeping their season series for the second straight year.
The San Francisco 49ers and other teams may need to find a temporary new home after Santa Clara County on Saturday banned all contact sports from holding games and practices for the next three weeks.
The San Francisco 49ers could be getting a handful key players back from injuries this week but may have to wait longer for six players on the COVID-19 list to return. Receiver Deebo Samuel has been cleared to return for Sunday's game.
The NFL suspended San Francisco 49ers cornerback K'Waun Williams for two games after he tested positive for performance-enhancing substances or PEDs.
Patrick Willis and Bryant Young, both former defenders for the San Francisco 49ers, were among the list of 25 semifinalists for the Pro Football Hall of Fame's class of 2021, which the organization revealed Tuesday.
Just weeks after a positive COVID-19 test kept several of the San Francisco 49ers' offensive weapons off the field, the virus appears to be plaguing the team's defense.
The San Francisco 49ers Monday announced they have placed defensive lineman Arik Armstead on the reserve/COVID-19 list.
Drew Brees was pulled at halftime with a rib injury after passing for just 76 yards and one touchdown but Alvin Kamara scored three times and New Orleans' defense largely stifled San Francisco to help the Saints secure a 27-13 victory.
Even as the surge in COVID cases nationwide creates increasing havoc across the college football landscape, NFL Commissioner Roger Goodell remains lasered focused on his league completing its season.
The San Francisco 49ers heard all about the Super Bowl runner-up curse before the start of this season, but the Niners felt they had the ingredients to buck that trend.
The San Francisco 49ers on Monday placed receiver Kendrick Bourne back on the COVID-19 list three days after removing him.
After a positive COVID-19 test took away four players from the San Francisco 49ers before their game against the Green Bay Packers, those same players tested negative for the virus twice, while one Packer was tested positive after the game.
Aaron Rodgers threw for 305 yards and four touchdowns and the Green Bay Packers overwhelmed the undermanned 49ers 34-17 on Thursday night.
Mere hours before the San Francisco 49ers take on the Green Bay Packers, 49ers wide receiver Kendrick Bourne tested negative for COVID-19, throwing his positive test from the day before into doubt.
The San Francisco 49ers announced Wednesday afternoon that the team would face the Green Bay Packers without LT Trent Williams and WR Brandon Aiyuk because they had close contact to WR Kendrick Bourne, who tested positive for COVID-19.
In a San Francisco 49ers regular season already awash with injuries, head coach Kyle Shanahan is now facing the very real possibility that starting quarterback Jimmy Garoppolo has been lost for the remainder of the year.
As the NFL Trading Deadline came and went Tuesday afternoon, the San Francisco 49ers announced they have waived former second round pick Dante Pettis, who never fulfilled the potential on the professional level that he achieved as star receiver at the University of Washington.
In a season marred by injuries, the San Francisco 49ers were dealt two more serious blows Monday as both star tight end George Kittle and starting quarterback Jimmy Garoppolo have again been sidelined and will miss games.
The Seattle Seahawks rebounded from their first loss of the season with a resounding 37-27 win over the San Francisco 49ers on Sunday.
El Niño conditions are 82% likely to return as soon as next month, with a 96% chance of it lasting through at least February, and there are increasing chances that the El Niño event will be moderate to very strong, but what does that mean?
This year's theme is La Copa Del Pueblo — The People's Cup, which celebrates soccer, the people who play it, and "honors the joy found in dusty fields, neighborhood parks, and busy city streets, where the game belongs to everyone and every goal feels like a shared victory."
The last year has been a hard time for the campus in general, due to huge budget cuts to sports and academic programs. But now there seems to be a renewed sense of optimism, not just for the graduates, but for the future of the university, as well.
San Francisco's tourism industry is showing signs of recovery this Memorial Day weekend as visitors crowd popular attractions like Fisherman's Wharf and the Golden Gate Bridge.
Harrison Bader hit a grand slam for the second time in six days, and the San Francisco Giants beats the Chicago White Sox 10-3.
El Niño conditions are 82% likely to return as soon as next month, with a 96% chance of it lasting through at least February, and there are increasing chances that the El Niño event will be moderate to very strong, but what does that mean?
This year's theme is La Copa Del Pueblo — The People's Cup, which celebrates soccer, the people who play it, and "honors the joy found in dusty fields, neighborhood parks, and busy city streets, where the game belongs to everyone and every goal feels like a shared victory."
The last year has been a hard time for the campus in general, due to huge budget cuts to sports and academic programs. But now there seems to be a renewed sense of optimism, not just for the graduates, but for the future of the university, as well.
San Francisco's tourism industry is showing signs of recovery this Memorial Day weekend as visitors crowd popular attractions like Fisherman's Wharf and the Golden Gate Bridge.
Harrison Bader hit a grand slam for the second time in six days, and the San Francisco Giants beats the Chicago White Sox 10-3.
This year's theme is La Copa Del Pueblo — The People's Cup, which celebrates soccer, the people who play it, and "honors the joy found in dusty fields, neighborhood parks, and busy city streets, where the game belongs to everyone and every goal feels like a shared victory."
San Francisco's tourism industry is showing signs of recovery this Memorial Day weekend as visitors crowd popular attractions like Fisherman's Wharf and the Golden Gate Bridge.
Daly City police said a 15-year-old allegedly stabbed a man at Westmoor High School after a graduation ceremony on Friday.
Opera singer Tim Blevins performs regularly outside San Francisco's Orpheum Theatre, where his powerful voice has become familiar to many passing through the Civic Center neighborhood.
The Waymo sped through a construction zone, was chased by police, then veered off the highway into a residential neighborhood during a ride from San Mateo to San Francisco.
It's a scene Bill Crislip has relived repeatedly for more than 25 years: a hit-and-run that killed his friend as he watched in stunned disbelief.
Three students were injured Friday during a chemistry class mishap at Heritage High School in Brentwood, according to fire officials.
A vegetation fire was burning in a remote area of eastern Contra Costa County on Thursday afternoon, Cal Fire said.
If approved by voters, "Measure E" would tax single-family homes $192 per year to go towards emergency services, public safety and clean streets. City leaders anticipate that the tax would raise about $34 million per year.
Oakland Mayor Barbara Lee is marking one year in office by touting the city's progress in its homelessness strategy, crime rate, and overall outlook.
Two men were arrested by law enforcement in Monterey County this week as part of an investigation into an organized rental construction equipment theft ring, authorities said.
A Santa Clara County juvenile court judge found a 14-year-old guilty of second-degree murder in the stabbing death of a 15-year-old at Santana Row in San Jose, prosecutors said.
Two Milpitas smoke shops have been cited for allegedly selling illegal products, including the highly-addictive substance kratom, from two smoke shops in Milpitas following concerns raised by community members.
A person suspected in multiple incidents of hateful graffiti found on the campus of San Jose State University has been arrested.
An alleged Monterey County gang member has been charged with six counts of murder in connection with a deadly mass shooting in King City, along with a separate shooting that killed two cousins in 2024.
The last year has been a hard time for the campus in general, due to huge budget cuts to sports and academic programs. But now there seems to be a renewed sense of optimism, not just for the graduates, but for the future of the university, as well.
Vallejo Fire crews responded just before 1:30 a.m. to a two-alarm structure fire at the former Grant School.
A high school teacher in Marin County was arrested and suspended from his job over alleged sexual misconduct involving a minor, police said.
A Vallejo man is suspected of killing a woman on May 1 and then shooting a man on Tuesday, before being arrested by officers, police said.
A North Bay man is being held on more than $1 million bail after he was arrested Tuesday in connection with a series of arsons in Sonoma County, authorities said.
Harrison Bader hit a grand slam for the second time in six days, and the San Francisco Giants beats the Chicago White Sox 10-3.
Rookie Munetaka Murakami hit a bases-clearing, bases-loaded double in his second plate appearance of a wild nine-run fourth inning, Andrew Benintendi doubled in two runs earlier in the frame to help back Davis Martin's latest strong outing, and the Chicago White Sox beat the San Francisco Giants 9-4.
Gabby Williams scored 16 points to lead a balanced offense and help the Golden State Valkyries rout the New York Liberty 87-70, spoiling the season debut of Satou Sabally.
Kyle Busch's family earlier Thursday announced he had been hospitalized with a "severe illness."
Gabby Williams knows all about the Bay Area, despite being a Nevada resident. She would travel from Reno to the Bay every spring and summer to play AAU basketball.
Daly City police said a 15-year-old allegedly stabbed a man at Westmoor High School after a graduation ceremony on Friday.
It's a scene Bill Crislip has relived repeatedly for more than 25 years: a hit-and-run that killed his friend as he watched in stunned disbelief.
Two men were arrested by law enforcement in Monterey County this week as part of an investigation into an organized rental construction equipment theft ring, authorities said.
A Santa Clara County juvenile court judge found a 14-year-old guilty of second-degree murder in the stabbing death of a 15-year-old at Santana Row in San Jose, prosecutors said.
Two Milpitas smoke shops have been cited for allegedly selling illegal products, including the highly-addictive substance kratom, from two smoke shops in Milpitas following concerns raised by community members.
The Waymo sped through a construction zone, was chased by police, then veered off the highway into a residential neighborhood during a ride from San Mateo to San Francisco.
Amid concern about AI taking jobs, people see a range of motives by AI companies.
AI tools that autonomously perform tasks for users mark a major step forward from chatbots, according to tech experts.
The first major step in saving the whales from ship strikes officially launched this week. A group of marine mammal experts gathered in San Francisco to launch Whale Spotter.
Ken Paxton notes that Meta Glasses are able to use cameras, speakers, and other components to capture data, including video and audio recordings and peoples' facial geometry.
WHO chief Tedros Adhanom Ghebreyesus says risks from the Ebola outbreak in Congo and Uganda are "high at the national and regional levels, and low at the global level."
The cruise ship hit by a deadly hantavirus outbreak has docked at the Dutch port of Rotterdam for disinfection, wrapping up a troubled journey that put world health authorities on alert.
At least 80 deaths have been reported in a new Ebola disease outbreak in Congo and Uganda, authorities said.
California public health officials said on Wednesday that they have identified a fifth resident who may have been exposed to the Andes hantavirus due to the outbreak on the MV Hondius cruise ship.
Health officials in Napa County are warning the public not to eat wild mushrooms after three people were poisoned.
California's soaring gas prices are fueling an escalating political battle between Gov. Gavin Newsom and Chevron, with Newsom urging drivers to boycott Chevron stations over Memorial Day weekend.
Rep. James Comer is requesting information from Kalshi and Polymarket on how the prediction markets guard against insider trading.
Tulsi Gabbard is resigning as the director of national intelligence after her husband was diagnosed with a rare form of bone cancer.
Amid concern about AI taking jobs, people see a range of motives by AI companies.
The Pentagon on Friday released a new batch of 64 files related to UFOs, unveiling a second tranche of records under an executive order by President Trump.
Jason Collins, the NBA's first openly gay player, who went on to become a pioneer for inclusion and an ambassador for the league, has died, his family announced Tuesday.
Philz Coffee will once again sport the Pride flag at its cafés after a directive to have them and other flags removed created a backlash.
The Trump administration agreed to restore the Stonewall National Monument's Pride flag in Greenwich Village after it was removed.
Philz Coffee's move to remove the Pride flag and all other flags from their stores is brewing up some strong reaction.
Transgender women athletes are now excluded from women's events at the Olympics after the IOC agreed to a new eligibility policy on Thursday.
This year's theme is La Copa Del Pueblo — The People's Cup, which celebrates soccer, the people who play it, and "honors the joy found in dusty fields, neighborhood parks, and busy city streets, where the game belongs to everyone and every goal feels like a shared victory."
Opera singer Tim Blevins performs regularly outside San Francisco's Orpheum Theatre, where his powerful voice has become familiar to many passing through the Civic Center neighborhood.
A former KFC - Taco Bell restaurant in San Francisco's Mission District is getting a new life, this time as a music studio aimed at supporting independent artists.
After nearly a century on the air, CBS News Radio signed off, with the final reports airing on Friday, May 22.
Stephen Colbert hosted "The Late Show" for the final time Thursday night as the franchise came to an end after 33 years.
Ever since the COVID-19 pandemic, the Oakland Unified School District has seen an alarming spike in the number of unhoused students in the school system who deal with a host of challenges far beyond what most children face.
Meteorologist and CBS News Bay Area's resident pilot Lt. Jessica Burch got a treat during Fleet Week, taking to the skies with one of the Blue Angels.
A Bay Area man discovered his devastating loss left him with a new opportunity to rethink how he lives -- follow his journey in virtual reality, 360-degree video.
A groundbreaking medical study involving the UCSF Medical Center has shown some colorectal cancer patients can safely skip radiation treatment and enjoy a potentially higher quality of life.
Every day, San Francisco bar pilot Captain Zach Kellerman goes through what might just be the world's most dangerous commute.
Da Lin reports on the San Francisco tourism industry.
with Zoe Mintz.
Meteorologist Zoe Mintz takes a look at El Nino 2026 for Zoomin with Zoe.
Meteorologist Zoe Mintz takes a look at El Nino 2026 for Zoomin with Zoe.
Napa businesses are expecting a boost in business as the BottleRock Festival brings many people to town.
In 2025, KPIX is moving to a new community service award: the CBS News Bay Area Icon Award. Submit nominations for an outstanding community hero at kpix.com/icon.
It's the most wonderful time of the year for a South Bay woman who has played Mrs. Claus for more than 40 years for the children of North San Jose's Alviso District.
For residents of the Oakland Hills, the prospect of another wildfire always remains a concern. This week's Jefferson Awards winner has made it his mission to make the hills and other high-risk areas safer.
In East Palo Alto -- where state education numbers show more than nine in ten public school students are low income and more than half are English learners -- many are finding hope and connection at the Boys & Girls Clubs of the Peninsula.
This week's Jefferson Award winner is Army veteran who continues to live a life of service into his 80s, by feeding hundreds of San Francisco families a week.
A Bay Area man who overcame tremendous obstacles to excel in school has made it his mission to gear up other students for success in the classroom and in life.
For Students Rising Above scholar Josh Collins it took moving across the country to realize the value of his Bay Area family.
Samir Hooker had to grow up fast after his stepfather was shot dead 12 years ago. Now he is watching over his mom and sister while attending UC Berkeley.
It's hard enough to graduate from one of the most prestigious schools in the country when you're the first in your family to go to college. Imagine doing that while you're also trying to protect your parents from being deported?
Some students who are the first in their families to go to college face the challenge of balancing a rigorous academic load while still working to help support their family back home.