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Brock Purdy and the Niners (4-0) get a chance to reverse that trend when they visit the defending Super Bowl champion Seahawks (3-1) for the first time this season.
San Francisco 49ers fullback Kyle Juszczyk has won his appeal over the fines issued by the NFL for what it deemed an "offensive" celebration when he imitated drinking a beverage, which the league said looked like he was chugging a beer.
Brock Purdy threw two touchdown passes and Christian McCaffrey ran for a score to lead the undefeated San Francisco 49ers to a 24-14 victory over the Denver Broncos.
The 49ers are the first team in 12 years to allow no sacks through three games as Purdy's elusiveness and strong play from the offense line have frustrated the opposition.
The San Francisco 49ers keep losing key players to injuries and still keep winning, thanks in large part to the play of quarterback Brock Purdy.
Several Bay Area high schools have pulled the plug on their varsity football teams' seasons because of not having enough players to field a team.
The NFL fined San Francisco 49ers All-Pro fullback Kyle Juszczyk for what it deemed an "offensive" celebration similar to one he had been doing for several years with no issues.
A high school on California's Central Coast has abruptly canceled the remainder of the 2026 football season as officials launch an investigation into the program.
Christian McCaffrey became the fourth-fastest player in the Super Bowl era with 100 career touchdowns, Brock Purdy played a near-perfect game and the San Francisco 49ers overwhelmed the Miami Dolphins 35-13.
Jaron-Keawe Sagapolutele threw for a career-high 413 yards and three touchdowns in California's 49-7 victory over Wagner.
The Niners take on the team with the longest odds to win it all this season as the biggest favorites in Week 2 against the Miami Dolphins in their home opener on Sunday.
San Francisco 49ers rookie receiver De'Zhaun Stribling is expected to miss at least two months after undergoing surgery on his injured left ankle.
Jaron-Keawe Sagapolutele threw for two touchdowns, and Kingston Lopa made three interceptions as California beat Syracuse 21-18 in an Atlantic Coast Conference opener for both teams.
Mike Evans, Demarcus Robinson and Deebo Samuel caught touchdown passes from Brock Purdy, and the San Francisco 49ers routed the Los Angeles Rams 27-7 in the first NFL regular-season game in Australia.
The longest road trip in NFL history has brought the San Francisco 49ers and the Los Angeles Rams to Australia's sports capital for a season opener in front of more than 100,000 football-hungry fans packed into the Southern Hemisphere's largest stadium.
San Francisco 49ers coach Kyle Shanahan says defensive tackle Alfred Collins is out for the season after tearing his patellar tendon.
Aaron Donald won't play Week 1, delaying his return to the field after ending his retirement last month.
San Francisco 49ers star pass rusher Nick Bosa is set to play in the season opener against the Los Angeles Rams in his first game action since a tearing a knee ligament last September.
Wayne Knight ran for two touchdowns in the fourth quarter following interceptions by Ta'Shawn James and UCLA opened the Bob Chesney era with a 45-24 victory over California.
The San Francisco 49ers have arrived in Melbourne for their season-opening NFL game against the Los Angeles Rams at the Melbourne Cricket Ground on Sept. 11.
Micah Ford scored his third touchdown on a 2-yard run with 1:41 to play and Stanford rallied after nearly blowing a 16-point lead in the fourth quarter to beat Hawaii 37-27 in the first game under new coach Tavita Pritchard.
Las Vegas rookie quarterback Fernando Mendoza saw what it was like Thursday night to face a strong NFL pass rush even against a San Francisco defense comprised of reserves.
California is taking the tarps off the seats in the south end zone of Memorial Stadium and is trending toward having its biggest home crowd in nearly a decade for its season opener against UCLA.
The San Francisco 49ers held their final practice before their exhibition finale with nearly two dozen injured players missing but remain hopeful that most will be able to return to practice next week before the team departs for Australia for the season opener.
San Francisco 49ers owner Jed York has pleaded no contest to two misdemeanor charges in Northeast Ohio after being arrested on suspicion of engaging in prostitution over the weekend, authorities said.
