San Francisco star linebacker Fred Warner was ruled out for the 49ers' divisional round playoff game against Seattle but could return from a serious ankle injury if the team wins this week.

Warner returned to practice this week for the first time since breaking and dislocating his right ankle in a loss at Tampa Bay on Oct. 12, with coach Kyle Shanahan initially describing it as a season-ending injury.

Warner had left open the possibility earlier this week that he could play on Saturday, but the 49ers ruled out that possibility Thursday. Shanahan said he remains hopeful that the four-time All-Pro could return if the Niners beat the Seahawks and advance to the NFC title game on Jan. 25.

"I do feel confident in that," Shanahan said. "We'll see if it works out."

The 49ers are hoping to get receiver Ricky Pearsall back this week after he missed the past two games and nine overall with a knee injury. Pearsall practiced on a limited basis all week and was listed as questionable.

Pearsall has 36 catches for 528 yards this season and leads San Francisco with eight catches on throws at least 20 yards downfield. Quarterback Brock Purdy hasn't completed any deep passes the past two games with Pearsall sidelined.

Shanahan said Pearsall has made improvement this week, but might not be able to handle a full workload if he does play.

"He's still battling it, so that's why he's still questionable," Shanahan said. "We would never put a guy on an exact snap count especially in a playoff game. But we also understand where he's at and that it would probably have to be different than his just true status of when he's 100% healthy."

Safety Ji'Ayir Brown is out against Seattle after injuring his hamstring last week, while linebackers Dee Winters (ankle) and Luke Gifford (quadriceps) are questionable. Receiver Jacob Cowing, who has been on IR all season with a hamstring injury, is also questionable.

Seahawks QB Sam Darnold listed as questionable

Seattle Seahawks quarterback Sam Darnold injured his left oblique during Thursday's practice and was listed as questionable for Saturday's NFC divisional playoff game against the San Francisco 49ers, but he said he's confident he'll play.

Darnold said he felt something in his oblique while throwing passes to receivers with no defenders.

"Didn't want to push it," Darnold said. "Wasn't the day to push it. That was it. Just came inside, got some rehab. Feel like I'll be ready to go for Saturday."

The eighth-year quarterback said this is the first time he has dealt with an oblique issue and that he'll be getting treatment leading up to the game. When asked about his chances of sitting out, Darnold said, "Very low percentage. Probably closer to zero."

Darnold passed for 4,048 yards with 25 touchdowns and 14 interceptions in his first season with the Seahawks, earning his second straight Pro Bowl selection. He led Seattle to a 14-3 record and the NFC's top seed.

Backup Drew Lock has appeared in five games this season and attempted just three passes. Lock started five games for the New York Giants in 2024 and has 28 career NFL starts, completing 59.6% of passes with 34 touchdowns and 28 interceptions.

"Drew's been really impressive throughout OTAs and training camp and in his role," offensive coordinator Klint Kubiak said. "A lot of confidence in Drew. Brought him here for a reason."

Nonetheless, the Seahawks hope Lock's services won't be needed.