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Doctors are trying to make an FDA-approved drug treatment for Amyotrophic Lateral Sclerosis, or ALS, much less intense for both patients and caregivers.
Michael Bloomberg is spending millions of dollars to drum up support for his presidential campaign in Pennsylvania.
A 16-year-old is facing charges after a shooting in Monroeville left a teenager in serious condition.
A new town has emerged in our region. It's JA BizTown, where 19 local businesses are operating, and they're all run by kids.
In the last month, 35 Pennsylvanians were charged with felony welfare fraud.
Mac Miller has hit the Billboard chart.
A postal service employee in Virginia says he put mail into a storage unit instead of delivering because he was overwhelmed, according to federal documents.
If you're behind on your child support payments, you might not be allowed to hunt or fish in Utah starting next year.
Pennsylvania wants to be a player in the presidential primary, instead of an afterthought.
Officials are searching for a wanted man.
The coronavirus outbreak that originated in Wuhan, China, has nothing to do with Corona beer, but some people seem to think it does.
Pittsburgh Police say a missing man from the West End was found dead in South Side.
Ohio is rolling out a new strategy to save Lake Erie from the toxic algae that overwhelms it in the summer.
Greensburg Police are working to find two strong-arm robbery suspects who are still at large.
For the first time in months, the NFL is shedding light on the Antonio Brown investigation.
Daisy met up with the master behind Liquid Flair in the latest installment of PTL Summer Spirits Week!
In anticipation of Picklesburgh, we're trying out Kool Aid Pickles on this Taste It Tuesday!
Heather, David and Ron are warming up their vocal cords for the the "CBS Mornings" Mixtape Music Competition.
Coming up on PTL (7/9)
Today on Talk Pittsburgh (7/9)
A person is in custody and the Parkway West is back open after a large police presence shut down the highway.
A Pennsylvania man won $1 million after buying a Powerball ticket while at the pharmacy to pick up a prescription for his wife, who had just had a heart attack.
A social media trend involving AI footage of Dr. Seuss' The Cat in the Hat is prompting warnings from school districts about safety.
Unless lawmakers intervene, skill game machines will be banned from most businesses in Pennsylvania starting Oct. 14.
Sen. John Fetterman's surprise video at the Republican Party's midterm convention sparked a strong reaction from Democrats.
Sen. John Fetterman's surprise video at the Republican Party's midterm convention sparked a strong reaction from Democrats.
Democratic Sen. John Fetterman appeared in a surprise video at the Republican Party's midterm convention on Wednesday, as he becomes increasingly isolated from his own party.
A Pennsylvania man is facing charges after police said he called Gov. Josh Shapiro's office and threatened to "destroy the Commonwealth."
The Trump administration moved Tuesday to ban imports of Canadian motorcycles, some dairy products and most types of alcohol starting later this month, intensifying the trade war between the two countries.
Pennsylvania could hold the key to which party controls the U.S. House of Representatives after November's midterm elections.
It seems like each week we get a new story or warning about a scam over the phone or on the internet. Here's how you can avoid them.
With proposed 50% tariffs on the table, the cost of new and used cars could increase by thousands in the near future.
A new report tries to calculate how much Pennsylvanians need to earn to live what's considered a comfortable lifestyle.
The store is expected to open sometime next year.
Buffalo Township police are warning about scammers after investigating several cases where residents have fallen victim.
Table Magazine's Arts & Culture Editor, Sean Collier, shares his top picks for weekend activities.
Participating Ford dealerships across the area are collecting food throughout the month, all leading up to the Steelers' home game on September 27th.
Kidsburgh Ambassador Yu-Ling Behr shares the places you can take your kids to learn something new.
The actor and Director of a new film join Heather and David to talk about their latest movie premiering in Pittsburgh in September!
Robby Incmikoski heads to the Carrie Blast Furnaces for a sneak peek of what to expect at this year's Pittsburgh Irish Festival!
The Steel City Youth Football League announced disciplinary action following video that captured an on-field brawl.
Misdemeanor and summary charges have been filed against the coaches involved in a youth football brawl in Pittsburgh.
Police departments all around the country say surveillance technologies like cameras, drones, and license plate readers have proved invaluable in tracking and arresting violent criminals.
Video shows youth football coaches from Carlynton and Keystone Oaks fighting on the field during a game over the weekend.
Police public safety services are being questioned in Forward Township.
Mental health days aren't just for adults; oftentimes, children need them, too, so here's what parents need to be on the lookout for.
Getting zapped by lightning is an enormous danger, and with an uptick in strikes in the Pittsburgh area, here's what you need to know.
A Pittsburgh-area mother is sharing her story after she says her daughter was exposed to measles at UPMC Children's Hospital.
Pennsylvania health officials said an out-of-state person tested positive for measles and may have exposed others at a Pennsylvania Turnpike service plaza in Westmoreland County.
Pennsylvania health officials say two people who had measles died in the state, but Health Secretary Robert F. Kennedy Jr. is questioning that.
Phil, the two-time champion, and Amanda, the Penguins' Manager of Minor League Operations, are both heading to the Hall of Fame.
The grant funding comes after a gunshot was fired near the district's high school football stadium last month.
Cameron Heyward is criticizing the franchise tag, calling it "stupid.".
AL Central-leading Chicago (75-70) maintained a two-game lead over Cleveland, which lost at Baltimore.
A Jeannette football player was diagnosed with leukemia after he was taken to the hospital during a game.
Many small businesses are still feeling the impact of last week's severe weather.
Pittsburgh leaders and their partners are making a concerted effort to revitalize a North Side business district.
A federally funded Ohio manufacturing program faces potential shutdown after a new audit by the U.S. Department of Commerce's Office of Inspector General.
Gas station giant Buc-ee's has sparked a backlash in Ohio over one of its frequent trademark infringement lawsuits.
The international fashion retailer Zara will open a location in Ross Park Mall in 2028, as the mall continues to thrive.
Local legend Donnie Iris will headline an early show at Pittsburgh's newest music venue, Citizens Live at The Wylie.
Dolly Parton died in Nashville on Aug. 25 at the age of 80 — a shock to fans around the world who weren't aware of her illness.
A show coming to The Palace Theatre in Greensburg looks to pay tribute to Dolly Parton.
Tim Curry was known for his iconic performances in cult classics like "The Rocky Horror Picture Show" and the original screen adaptation of Stephen King's "It."
Pittsburghers are remembering Dolly Parton as "one of a kind" following her death on Tuesday.
A Pittsburgh-area hospital is seeing a concerning uptick in withdrawals from what many describe as "gas station heroin." KDKA's Jessica Riley reports.
Sen. John Fetterman's surprise video at the Republican Party's midterm convention sparked a strong reaction from Democrats.
Around two dozen people showed up outside the Westmoreland County Courthouse on Thursday to protest District Attorney Nicole Ziccarelli. KDKA-TV's Chris DeRose reports.
We're talking about the latest stories from KDKA Investigates.
A musical about 9/11 might not sound like an obvious recipe for an uplifting night at the theater, but that's exactly what makes "Come From Away" so special. It's a story about the detoured planes that couldn't make their destinations, strangers who opened their homes and a community that found unexpected ways to bring people together. It's taking the stage through theatre company Mon Rivers Arts in Elizabeth.
Mike Tomlin stepped down as head coach of the Pittsburgh Steelers after 19 seasons with the team.
Pitt's regular season has ended with an 8-4 record.
Pitt's five-game winning streak came to an end with a 37-15 loss to Notre Dame.
Mason Heintschel set a new Pitt freshman single-game passing record in the Pitt win at Acrisure Stadium.
The 44th annual KDKA-TV Turkey Fund will help our neighbors in need have a nice meal for Thanksgiving.
