Other featured acts include Wilco, Ben Harper and the Innocent Criminals, Sinead O'Connor, Fall Out Boy, Mute Math, Plain White T's and The Black Crowes.
The three-day festival at City Park opens Oct. 26.
Some 90,000 fans attended last fall's festival, headlined by the Red Hot Chili Peppers and Duran Duran. That turnout prompted organizers to expand the event from two days to three. The festival also ran three days in 2003.
Steve Rehage, whose company, Rehage Entertainment Inc., produces the Voodoo Music Experience, said he's proud of the lineup. It's one he hopes "demands national attention and makes people think, 'Wow, cool things still happen in New Orleans. Let's go.' "