The third installment of the Sam Raimi-directed franchise will debut in the New York City borough of Queens, the hometown of Peter Parker, Spider-Man's alter ego. The premiere will kick off a planned "Spider-Man Week in NYC," which will include events and promotions throughout the city.
"Tribeca is thrilled to be premiering `Spider-Man 3' and to be a part of `Spider-Man Week in NYC,'" Tribeca co-founder Jane Rosenthal said in a statement. "Bringing exciting and new events to NYC and its community is one of the major goals of the festival."
The U.S. premiere of the much anticipated Columbia Pictures release will be the last stop on an eight-city world tour to begin April 16 in Tokyo.
The film, starring Tobey Maguire and Kirsten Dunst, opens worldwide May 4. This installment introduces two new villains to the series: Sandman (Thomas Haden Church) and Venom (Topher Grace).
The Tribeca Film Festival was founded in 2002 by Robert De Niro and Rosenthal to help revitalize Lower Manhattan after the terrorist attacks on the World Trade Center.
The sixth annual festival will run from April 25 through May 6.