Fresh off his Oscar win for "The Departed," the acclaimed director will give a master class on moviemaking to students and film buffs on May 24, the festival announced.
During the May 27 closing ceremony in Cannes, Scorsese will present a prize for the best film by a first-time director.
Also in Cannes, he is scheduled to announce the creation of a new foundation "devoted to the preservation and restoration of the masterpieces of world cinema," the festival said.
Scorsese, 64, won Cannes' top prize for his film "Taxi Driver" in 1976.
Photos: Martin Scorsese
The festival, which runs May 16-27, celebrates its 60th anniversary this year.