Just 10 days after the high of winning an Academy Award for Best Actress, she learned of an alleged affair her husband, Jesse James, had with tattoo model Michelle "Bombshell" McGee.
"The Blind Side" star has since moved out of the Los Angeles home she shared with James and cancelled appearances at international premieres and award shows, as well as refusing to address her husband's supposed infidelities.
And now, more women are coming out of the woodwork. According to reports, the count is currently up to five claiming to have had an affair with James.
So, has she had enough?
According to Radar Online and US Weekly, the answer is "yes."
Radar Online reports sources say Bullock "has made up her mind" and "she's ending the marriage."
Bradley Jacobs, senior editor of US Weekly, said on "The Early Show," US has learned from a friend of Bullock's that the star "definitely" wants a divorce.
"She's not going back to him. She's not interested in the excuses. She's been speaking with her lawyer," Jacobs said. "So I think it's just a matter of time."
However, Bullock isn't through with her stepdaughter Sunny, Bradley said. US has reported that she's looking to get custody of the 6-year-old girl, Bradley said.
Jacobs said on "The Early Show," "Think about it, Sandra's been married to Jesse for five years and they have raised this girl together. Her mother, her biological mother, is in a halfway house, she was a former porn star, she's an admitted drug addict. So basically Sandra has been this girl's mother. Now she wants to divorce Jesse, but she still wants to raise Sunny. It's an interesting legal question, because Sandra, of course, is not the biological (mother) or (has any) legal claims to this girl. But she basically is her mother."
Bullock's representatives have denied the star is seeking custody.
James is currently in a rehabilitation facility for sex and drug addiction, according to Radar Online and US Weekly.