The "Kill Bill" and "Pulp Fiction" director, who occasionally drops in on television, will direct the hourlong season finale of the CBS crime drama, the network said.
He's also helping create the story, in which a member of the "CSI" team faces danger, CBS said. An air date wasn't announced.
Tarantino had a recurring guest role on the ABC spy saga "Alias" and directed an episode of NBC's "ER." His films are known for their stylized violence.
The first of the three "CSI" dramas, the series stars William Petersen and Marg Helgenberger. It airs 9 p.m. EST Thursdays.