Jane Kaczmarek

Actress Jane Kaczmarek poses with a pair of ruby red slippers that she designed for the gala screening of "The Wizard of Oz" marking the movie classic's 50th anniversary at the Academy of Motion Picture Arts and Sciences Samuel Goldwyn Theatre October 19, 2005 in Beverly Hills, California.
GETTY IMAGES/Matthew Simmons
Wisconsin native Jane Kaczmarek majored in theater at the University of Wisconsin and broke into the profession first at a small company with pal Tony Shalhoub (also a 2006 nominee). That later led her to Broadway, where she appeared in the hit "Lost in Yonkers."

Kaczmarek guest-starred on a slew of 90's TV series, including "Picket Fences," "Frasier," "Party of Five," and "Felicity." She landed her "Malcolm in the Middle" role as Lois, a harried mother of four, in 2000 and has received a whopping seven Emmy nods.

She is married to "West Wing" actor Bradley Whitford. They have three children.