Witherspoon plays a by-the-book police officer who has to protect Vergara's mob widow in the new comedy, "Hot Pursuit."
Both stars, who serve as executive producers on the film, note how the movie isn't "about a bunch of guys or us chasing guys. It's really about two women helping themselves."
The two women say had been trying to find a project to work on together for years.
Check out the video above for more on "Hot Pursuit" and to hear about Witherspoon and Vergara's favorite scenes.
"Hot Pursuit" opens in theaters Friday.