The presidential candidate also said she would bar political appointees from altering or removing scientific conclusions from government research without a legitimate reason for doing so.
"The Bush administration has declared war on science," the New York senator said. "When I am president, scientific integrity will not be the exception it will be the rule."
Her address to the Carnegie Institution for Science was timed to coincide with the 50th anniversary of the launch of the Sputnik satellite by the Soviet Union. The launch, which caught U.S. scientists by surprise, helped start the U.S.-Soviet space race and led to the creation of National Aeronautics and Space Administration.
The candidate said as a little girl she was fascinated by Sputnik, but that today's scientific challenges often come from political ideology instead of foreign powers.
"For six and half years under this president, it's been open season on open inquiry," Clinton said. "By ignoring or manipulating science, the Bush administration is letting our economic competitors get an edge in the global economy. I believe we have to change course, and I know America is ready."
She said Mr. Bush's limits on federal funds for embryonic stem cell research amounts to a "ban on hope."
On the campaign trail, Clinton has repeatedly slammed what she calls Mr. Bush's "war on science" and accused the administration of allowing conservative political ideology to interfere with research and scientific evidence. She cites administration officials who have questioned the scientific evidence of global warming and who have suggested a link existed between abortion and breast cancer.
As president, Clinton said she would: