The event, hosted by Jessica Alba, will be filmed June 3 at Sony Picture Studios in Culver City, Calif. The show will air June 8 at 9 p.m. EDT.
Aguilera will perform and debut music from her new album, "Back to Basics," the network announced Monday. She last performed at the MTV Movie Awards in 2001.
Punk rock band AFI will perform songs from their new album, "Decemberunderground," slated for release June 6.
Presenters will include Kate Beckinsale, Jamie Foxx, Owen Wilson, Justin Timberlake, Matt Dillon, Will Ferrell, Kate Hudson, Rebecca Romijn, Kate Bosworth and rappers T.I. and Ludacris.