PHOENIX (CBS / AP) -- Matt Cain had his third strong outing in three appearances this season and Pablo Sandoval hit a three-run homer to lift the San Francisco Giants to their third straight victory, 5-2 over the Arizona Diamondbacks on Friday night.

Cain (2-0) allowed one run on four hits in six innings—plus two batters. The right-hander, coming off a superb postseason, threw six scoreless innings, then gave up a popup double down the right field line to Stephen Drew and hit Melvin Mora to end his night in the seventh. Drew later scored, just the third run charged to Cain in 19-plus innings this season.

Sandoval's third homer of the year, off Daniel Hudson in the first inning, provided all the offense the Giants needed. Sandoval also walked and scored on the first of Miguel Tejada's two doubles.

Hudson (0-3) matched his career best with 10 strikeouts but allowed five runs, four earned, on six hits and three walks in six innings.

Brian Wilson came on with runners at first and second and two outs in the ninth. He gave up an RBI single to Willie Bloomquist before getting slumping Kelly Johnson to pop out for his third save in four tries.

With one out in the first, Freddy Sanchez singled off the glove of third baseman Melvin Mora, then Buster Posey singled up the middle to bring up Sandoval. With two outs, on a 1-0 pitch, the still big—but not as big as before after an offseason conditioning program—hit a towering shot over the swimming pool in right field to put the Giants up 3-0.

San Francisco added one in the fourth when Sandoval drew a leadoff walk, Brandon Belt singled and Tejada doubled down thhe left field line. Cain followed with a low liner to right fielder Justin Upton, who made the catch and threw home as Belt was held at third. Upton had two singles off Cain.

The Giants scored an unearned run in the fifth. After Aubrey Huff walked and Posey singled, San Francisco went with a double-steal. Catcher Miguel Montero threw wild to third allowing a runner to score and make it 5-0.

After Cain departed in the seventh, left-hander Jeremy Affeldt fanned Montero but walked pinch-hitter Xavier Nagy to load the bases. Bloomquist's RBI sacrifice fly off reliever Ramon Ramirez ended the shutout.

NOTES: Giants RHP Tim Lincecum is donating $25,000 to the Bryan Stow Fund to benefit the San Francisco fan critically injured in an attack following the season opener at Dodger Stadium on March 31. ... Bloomquist stole his seventh base of the season. ... Hudson got his third hit in five at-bats. ... Johnson robbed Sanchez of a hit with a sliding catch behind first base to start the fifth. ... Johnson was 0 for 5.

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