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Coach Jim Harbaugh announced the move Monday, a day after his team's 28-17 win at Dallas. James has sought a greater role in the running game, but he had just two carries for no yards against the Cowboys on Sunday.
Here is how players, sports pros and regular folks reacted to Ray Rice's suspension on Twitter.
The Baltimore Ravens have cut running back Ray Rice.
All the problems that seemed to be facing the 49ers were worked out on the field. The offense looked fine, the defense stepped up and the result was a road win, that was far from a lock. f the 49ers can continue to improve, they will be back in the thick of things at the end of the season.
The Oakland Raiders defense bent a lot on Sunday in New York, but it didn't break much. Unfortunately, that wasn't enough for rookie QB Derek Carr to get a win in his first NFL start as the Jets won the game, 19-14.
Colin Kaepernick and the San Francisco 49ers can put a tumultuous offseason behind them. They have a rusty Tony Romo to thank for making the opener a little easier.
Derek Carr held his own for two quarters, looking as though just maybe he could help end the Oakland Raiders' woes in the East.