"When he's on his game, he's pretty tough to beat, so I just had to go up there and put up goose eggs up, just like him," Wells said. "Hopefully, you wait him out, and that's what happened. We got to him, and he started getting frustrated out there, so I went out there more focused."
Colon (9-8) tied a Bob Feller's Indians record, set in 1938 against Detroit, by striking out his first six batters. Colon struggled after that, giving up a career-high four homers and allowing seven runs and six hits in 5 1-3 innings.
Wells (16-3), winless in his previous two starts after defeating Montreal on July 8, pitched his league-leading fifth complete game of the season, improving to 13-3 against Cleveland in his career. He struck out 11, matching his season high, and walked one.
"After he saw Colon strike out the first six, Boomer reached back," Toronto manager Jim Fregosi said.
Fullmer had the second multihomer game of his career, raising his season total to 20. The Blue Jays have five players with 20 or more homers for the first time in franchise history.
"We have the best offense in the majors," Fullmer said. "We've been consistent all year. We have a lot of guys who can hit the ball a long way."
Shannon Stewart led off the fourth with a homer, and Fullmer hit a two-run drive later in the inning.
"After Stewart hit that homer, Colon got away from the strike zone," Cleveland manager Charlie Manuel said.
Toronto added two runs in the sixth off Jaime Navarro on Gonzalez's RBI double and Stewart's run-scoring single.
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