On the red carpet Shakira told Judy Faber of The Showbuzz, "It's going to be a very emotional night, I think. Just the mere fact that I'm going to be meeting with so many of my friends and colleagues and sharing the stage with them. It's something, you know?"
She also earned best female pop vocal album, and her recording team took home honors for best engineered album. She was the leading nominee going in to the show with five nominations.
She lost best short form video, which went to Puerto Rico reggaeton group Calle 13. They took home a total of two awards, as did Argentine rock legend Gustavo Cerati.
Earlier in the evening, Shakira sang her ballad "La Pared" seated sweetly on a stool, and after changing into tight leggings and a midriff-baring top she joined Alejandro Sanz for a performance of "La Tortura."
Perhaps her next win will be a Nobel Prize for science because the way she's able to isolate her torso and hip movements is certainly a feat of engineering.
Andrea Bocelli performed songs from his album "Amor" which was nominated for best male pop album. "This was my first album recorded almost completely in Spanish," he told The Showbuzz. "It was a big challenge for me and for this reason I'm very happy to be here."
Ricky Martin picked up this year's Person Of The Year award for his humanitarian work in the fight against human trafficking. Martin had the audience on their feet and dancing with his performance of two songs from his upcoming MTV Unplugged album.
"We are here fighting for all of you," he said, referring to victims of human trafficking. "And to the traffickers: we're at war and God will bless us."