Promoter Bob Arum says if that doesn't happen by Thursday, the proposed March 13 fight that would have likely been the richest ever in boxing is over.
"As far as I'm concerned, the fight is off." Arum told Reuters in a telephone interview. "We don't object to more extensive drug testing, even though it's certainly not required in Nevada."
Arum accused Mayweather's camp of raising the issue not because they were worried about Pacquiao taking performance-enhancing substances, but because Mayweather never wanted to fight in the first place.
Arum said Wednesday that Pacquiao would agree to testing by the same agencies that test pro football and baseball players, but not for random tests by the U.S. Anti-Doping Agency.
"What we're saying is that the drug testing he is proposing is intrusive and would disturb Pacquiao's training if it's done within 30 days of his fight."
He said that Pacquiao still plans to fight March 13, and will now look for another opponent.