The former Black Sabbath front man, 61, admits abusing drugs and alcohol for decades.
Britain's Sky News says he recently called himself as a "medical miracle" after going on a "bender" for "40 years." In 2003, he broke his neck in a quad bike accident.
And now, the British TV network reports, scientists are mapping Osbourne's genetic code to try to see what makes him tick.
He's "only one of a few people in the world to have his full genome analyzed," Sky News points out.
It's being done by the Cambridge, Mass.-based company Knome, and should take about three months.
Researchers hope the mapping sheds light on, among other things, how drugs are absorbed in the body.
Sky News quotes Nathan Pearson, director of research at the firm, as saying, "Sequencing and analyzing individuals with extreme medical histories provides the greatest potential scientific value."