"I respectfully ask that the media allow me to receive care and heal in private during this difficult time," Wilson said in a statement released through publicist Ina Treciokas.
No further comments were expected, she said.
The actor was at Cedars-Sinai Medical Center in Los Angeles. He was transferred there from St. John's Health Center in Santa Monica.
It was not known why he was hospitalized, but Santa Monica Fire Battalion Chief Jose Torres said Monday that the department responded to a call that involved the 38-year-old actor.
The chief would not comment on Wilson's injuries or condition, citing federal privacy laws.
"These guys were kind of taking their time taking a stretcher out of the ambulance, then they went into the house," said neighbor Geoffry White, 61, who lives directly across the street from the actor.
According to "Entertainment Tonight," Wilson was later brought to the Beverly Hills' Cedars-Sinai Hospital where he detoxed. Anonymous sources said Wilson suffered from dehydration. The show also reported that brother Luke Wilson was spotted leaving Cedars-Sinai on Sunday night with their brother, Andrew. People magazine said Owen's parents also visited.
Most recently, he starred in "Night at the Museum," with Stiller and is slated to star in the film adaptation of the book "Marley and Me."