The two-part television interview, titled "O.J. Simpson: If I Did It, Here's How It Happened," will air Nov. 27 and Nov. 29 on Fox, the TV network said Tuesday.
"O.J. Simpson, in his own words, tells for the first time how he would have committed the murders if he were the one responsible for the crimes," the network said in a statement. "In the two-part event, Simpson describes how he would have carried out the murders he has vehemently denied committing for over a decade."
"This is an interview that no one thought would ever happen. It's the definitive last chapter in the Trial of the Century," Mike Darnell, executive vice president of alternative programming for Fox, said in a statement.
In a video clip on the network's Web site, an off-screen interviewer says to Simpson, "You wrote 'I have never seen so much blood in my life."'
"I don't think any two people could be murdered without everybody being covered in blood," Simpson responds.
In recent years, Simpson has made a living signing autographs at trade shows. But according to the National Enquirer, he's being paid $3.5 million for his story, reports CBS News Early Show national correspondent Hattie Kaufman.
The interview, conducted with book publisher Judith Regan, will air days before Simpson's new book, "If I Did It," goes on sale Nov. 30. The book "hypothetically describes how the murders would have been committed," the network said.
The book is published by ReganBooks, an imprint of HarperCollins Publishers run by Regan.
Simpson, who now lives in Florida, was acquitted in a criminal trial of the 1994 killings of his ex-wife, Nicole Brown Simpson, and her friend Ronald Goldman. Simpson was later found liable in 1997 in a wrongful death lawsuit filed by the Goldman family.
In September, Goldman's father, Fred, asked a court toto the name, image and likeness of Simpson, who has failed to pay the $33.5 million judgment in the lawsuit. However, a Santa Monica court rejected Goldman's claim two weeks ago.
"He personally has never paid a dime on the judgment to anyone," Fred Goldman said. "He has made it very clear over the years that he has no intention of doing so."
Messages left with Simpson and his attorney Yale Galanter were not returned Tuesday night.