"There was absolutely no vision for American foreign policy," Axelrod said on "CBS This Morning" Wednesday.
In his speech Tuesday, Romney knocked the president, without naming him, for not having a "vision to lead." He also criticized the leaking of national security information and the automatic defense cuts set to take place at the beginning of the year.
Axelrod, however, defended the president's foreign policy and said Romney offered the country nothing by attacking it.
"His critiques were nonsense. He wants to talk about anything other than a president who responsibility ended the war in Iraq, brought Osama bin Laden to justice and rebuilt our alliances. That's a very proud record and the American people know that," Axelrod said.
"How can you speak to a veteran's organization and never mention al Qaeda ... and never talk about veterans? Gov. Romney is the one who isn't meeting the test," Axelrod added.
The president's adviser also dismissed criticism after Sen. Dianne Feinstein, D-Calif, said, before taking back her comments, that the White House had leaked national security information.
"She has no information about where these leaks came from; the two authors from the books in question said their leaks didn't come from the White House," he said.
Axelrod agreed that the Obama campaign is guilty of airing negative television advertisements in battleground states, saying the president must defend itself from $100 million worth of negative ads by Romney and his supporters. He insisted, though, that the Obama campaign has also distributed positive ads.
"Look at the ad we are running now, and it lays out a very specific choice about how we're going to lead our economy. We've been for a full month laying out the record of the last 3 1/2 years on television in these battleground states," Axelrod said. "I've yet to see Gov. Romney match that in his own advertising."
"Gov. Romney has many, many questions to answer about what he'll do in the future and what he's done in the past, and he hopes to not talk about any of it," Axelrod said.