Stored for 43 years, the items include her Joe DiMaggio divorce papers, her personal phone directory and an original watercolor painting Monroe made and inscribed to President Kennedy for his birthday.
The actress died in August 1962 before giving the painting of a rose to Kennedy.
The auction will be conducted by Julien's Auctions of Los Angeles/New York at Barclay Butera in Los Angeles on June 4. The items will be on display May 31-June 3.
Items in the auction also include her 1956 application to a New York City court to change her name from Norma Jean Mortenson to Marilyn Monroe and a pearl gray silk dress she wore in the 1960 film "Let's Make Love."
"This is the first time that most of these items will be seen by the public, including a dizzying array of clothing from all the designers she cherished," Darren Julien, president and CEO of Julien's Auctions, said in a recent statement.
"Her personal telephone directory contains hundreds of names and numbers of top Hollywood celebrities including Frank Sinatra, Henry Fonda, Jane Russell and even former husbands Joe DiMaggio and Arthur Miller," Julien said.
Monroe, who died at 36 of a drug overdose, was married to DiMaggio for 21 months; they were divorced in 1955. She had earlier been married to James Dougherty, and later to playwright Arthur Miller.
The jewelry of another Hollywood star, Ann Miller, also will be sold June 4.