At 2:45 p.m. on Monday, second grader Somer Thompson was last seen walking home with her siblings and friends from Grove Park Elementary School.
Detectives say Somer and her friends argued; she ran ahead and hasn't been seen since.
An Amber Alert wasn't issued at first because no one witnessed Somer's disappearance and there was no description of a vehicle.
An Amber Alert was finally issued at 9:00 a.m. Tuesday and 150 law enforcement officers began to search.
Somer Thompson's mother Deana Thompson and Clay County Sheriff Rick Beseler joined "The Early Show" to talk about the case.
Asked to describe her daughter, Thompson said, "She's a beautiful 7-year-old, doesn't know a stranger. She's loving, she's creative. Has a twin, and he wants her to come home."
"We just want her to come home," she said.
Deana Thompson had a message for her daughter: "I just want her to come home, no matter what, she's not in trouble. We're not upset with her. And we will never give up looking for you, Somer."
"Please, please just let her come home to me. Drop her off somewhere. Just put her on a corner and let her come home," she added.
Sheriff Beseler told co-anchor Maggie Rodriguez they need help from the public, pleading for anyone with information to call the authorities.
The Clay County Sheriff's Office can be reached at (904) 284-0710.