"The best way to deal with a pandemic is to isolate it and keep it isolated in the region in which it begins," he said during a wide-ranging Rose Garden news conference.
The president was asked if his recent talk of giving the military the lead in responding to large natural disasters such as Hurricane Katrina and other catastrophes was in part the result of his concerns that state and local personnel aren't up to the task of a flu outbreak.
"Yes," he replied.
After the bungled initial federal response to Katrina, Bush suggested putting the Pentagon in charge of search-and-rescue efforts in times of a major terrorist attack or similarly catastrophic natural disaster. He has argued that the armed forces have the ability to quickly mobilize the equipment, manpower and communications capabilities needed in times of crisis.
But such a shift could require a change in law, and some in Congress and the states worry it would increase the power of the federal government at the expense of local control.
Bush made clear that the potential for an outbreak of avian flu is much on his mind, and has him talking with "as many (world) leaders as I could find" and reading a book on the 1918 Spanish flu pandemic that killed 40 million and consulting staff and experts.
"I have thought through the scenarios of what an avian flu outbreak could mean," he said.
He acknowledged that a quarantine — an idea sure to alarm many in the public — is no small thing for the government to undertake and that enforcing it would be tricky.
"It's one thing to shut down airplanes," Bush said. "It's another thing to prevent people from coming in to get exposed to the avian flu."
He urged Congress to give him the ability to use the military, if needed.
"I think the president ought to have all ... assets on the table to be able to deal with something this significant," he said.
Bush also said he has been urging world leaders to improve reporting on outbreaks of the virus, and exploring how to speed the production of a spray, now in limited supply, that "can maybe help arrest the spread of the disease."
"One of the issues is how do we encourage the manufacturing capacity of the country, and maybe the world, to be prepared to deal with the outbreak of a pandemic?" he said.
Experts agree there will certainly be another flu pandemic — a new human flu strain that goes global. However, it is unknown when or how bad that global epidemic will be — or whether the H5N1 bird flu strain now circulating in Asian poultry will be its origin.
Just in case, experts are tracking the avian flu, which has swept through poultry populations in large swaths of Asia since 2003, jumped to humans and killed at least 65 people.
Most human cases have been linked to a contact with sick birds, but the World Health Organization has warned the virus could mutate into a form that spreads easily among humans — changing it from a bird virus to a human pandemic flu strain.