Thecarried some of the first European settlers across the Atlantic Ocean to North America, 400 years ago this year.
To commemorate the anniversary, another vessel is recreating that voyage, with the help of.
"We don't know how it's going to go. Is it going to make it across the Atlantic?" software engineer and emerging technology specialist Rosie Lickorish told CBS News' Roxana Saberi. "Fingers crossed that it does have a successful first voyage."
The vessel, docked in the harbor of Plymouth, England, will rely on the latest navigation technology when it sets out to sea — but it won't be carrying a crew or captain.
"We've got all sorts of cameras… We've got global positioning systems on either side," robotics expert Brett Phaneuf said.
What it won't have, he said, is "people space."
Instead the ship will be guided by artificial intelligence designed by.
Phaneuf explained how the technology is supposed to work.
"It looks at its own cameras like eyes, it looks at the radar, it looks at all sorts of other sensors," he said. "Then it charts its own course and it can deal with unique situations without any human input."
Those situations include encountering other ships during the voyage — something software engineer Ollie Thompson is working hard to train the ship's programming to recognize using more than a million different images.
"We're simulating what she's seeing," he said of the boat.
Programmers are also setting the ship's destination to Plymouth, Massachusetts to retrace the Mayflower's four centuries-old passage.
It took the wooden merchant ship 66 days to transport dozens of pilgrims across the Atlantic.
A replica sailed from England to Massachusetts in the 1950s, and is still docked there today.
But Phenauf, who grew up near Plymouth, Massachusetts, wanted to mark the Mayflower's famous past by looking ahead instead.
"I thought, well, we should build a ship that speaks to the next 400 years. What the marine enterprise will look like then, as opposed to what it looked like 400 years ago," he said.
An international team turned his vision into the solar-and-wind-powered Mayflower autonomous ship. Its mission is to learn more about Earth's oceans by gathering data on plastic pollution, warming waters and their effects on marine life.
Software developer Rosie Likorish said the autonomous ship is a more cost-effective way to perform the research.
"It's very expensive at the moment for scientists actually go out on these research missions," she said. "So having autonomous vessels like the Mayflower Autonomous Ship is a really important step and kind of actually enabling us to go out to these dangerous places and learn a lot more."
In addition to cost-saving, not having a crew means the size of the vessel can be compact, and there are no concerns over someone getting sick or hurt.
Brett Phenauf said his biggest worry would be if something broke.
If the boat capsized, the team plans to track it via satellite and salvage it.
And if the unknown voyage succeeds, Phenauf says it would commemorate history while charting a new path.
He said, "I want people to look back on this 400 years from now and think about how different this was from what other people were doing."