The president began a speech late Saturday at the 91st annual White House Correspondents' Association dinner, but was quickly "interrupted" by his wife in an obviously planned ploy.
"Not that old joke, not again," she said to the delight of the audience. "I've been attending these dinners for years and just quietly sitting there. I've got a few things I want to say for a change."
The president sat down and she proceeded to note that he is "usually in bed by now" and said she told him recently, "If you really want to end tyranny in the world, you're going to have to stay up later."
She outlined a typical evening: "Nine o'clock, Mr. Excitement here is sound asleep and I'm watching `Desperate Housewives'." Comedic pause. "With Lynne Cheney. Ladies and gentlemen, I am a desperate housewife."
The line earned particularly rambunctious applause from the area of the Hilton Washington hotel ballroom where actor James Denton from the hit ABC show sat.
Laura Bush added that she and her husband obviously were destined to be together as a couple because "I was the librarian who spent 12 hours a day in the library and yet somehow I met George."
The guest professional comedian, Cedric the Entertainer, next came to the microphone to deliver one-liners, but not before conceding the first lady was a hard act to follow.
Joining the Bushes were Vice President Dick Cheney and wife, Lynne. News organizations hosted show business and sports stars such as Goldie Hawn, Richard Gere, Jane Fonda, Mary Tyler Moore, tennis sisters Venus and Serena Williams and a few supermodels.
Presidents since Calvin Coolidge have attended the dinner hosted by the association, which was established in 1914 as a bridge between the press corps and the White House.
Award winners announced earlier this month: