"CBS Evening News" anchor and Managing Editor Katie Couric plans to be With Smith as he gets ready for and has the colonoscopy at NewYork-Presbyterian Hospital/Weill Cornell Medical Center.
The procedure will be performed by Dr. Mark Pochapin.
It will be the first time an anchor has had a colonoscopy live on network television.
Smith and Couric will be recognizing National Colorectal Cancer Awareness month.
Couric had an on-air colonoscopy in 2000 and afterwards, University of Michigan researchers documented a 20 percent increase in the number of colonoscopies performed across the country. They dubbed it "The Couric Effect."
In addition to following Smith throughout his colonoscopy, viewers will get a tour, conducted by Couric, of the Jay Monahan Center for Gastrointestinal Health at NewYork-Presbyterian/Weill Cornell, named in honor of her late husband.
After losing him to colon cancer in 1998, Couric embraced the fight against the disease, becoming a leading advocate. In March 2000, Couric launched the National Colorectal Cancer Research Alliance with the Entertainment Industry Foundation and Lilly Tartikoff to support cutting-edge research and to conduct educational programs encouraging prevention and early detection, through screenings, of this country's second-leading cancer killer. Couric is also a co-founder of Stand Up To Cancer, which raises funds to accelerate groundbreaking research being conducted on various types of cancer by teams of scientists from different institutions.