The Early Show national correspondent Hattie Kauffman reports it also marked the first time a certain superstar took the Grammy stage.
Though Paul McCartney's performance left the audience begging for more, the ex-Beatle was beaten out for best pop album by an "American Idol," Kelly Clarkson, who ended the night with two Grammys, and cried during an emotional acceptance speech, saying, "Thank you so much. You have no idea what this means to me."
Backstage later, Kauffman asked Clarkson if she'd ever felt she had to prove herself, since she'd gotten her start from the reality show.
"No," Clarkson quickly replied. "I never felt that. Everybody gets in the industry in some manner or form. Everyone usually knows someone who gets you there. So, it's just that one time that it happens, then that's your chance, and you take it and you run with it, or you take it and you sit on it. And I'm running with it."
U2 grabbed five Grammys, bringing the group's total to 20. Among them: album of the year, best rock album and song of the year.
And they rocked the house with a performance during the show, with a little help from Mary J. Blige.
Also performing was Mariah Carey, who won best new artist in 1990. She solidified her comeback with three more Grammys.
"The first time I performed at the Grammys, I was just really young and nervous, and I just kinda held my breath the whole time," she told Kauffman.
How did Carey sing while holding her breath?
"You hold your breath and you sing and you're, like, nervous and you're tense and you're uptight, and of course we all have those moments," she said.