(CBS) -- A driver headed the wrong way on the Veterans Memorial Tollway set off a deadly chain reaction crash late Thursday night.

Illinois State Police said a Volkswagen Jetta was headed south in the northbound lanes of Interstate 355 near Maple Avenue in Downers Grove shortly before 11 p.m., when it slammed into a Honda Accord, setting off a crash involving a Ford box truck and a silver Subaru.

The driver of the Volkswsagen, 36-year-old Robert Velazco, was pronounced dead at the scene, police said. The driver of the Honda, 32-year-old Dr. Arshad Mohammed, died at the hospital.

Mohammed was a first-year orthodontic resident at the University of Illinois at Chicago, originally from Hyderabad, India.

The driver and two passengers in the Subaru suffered life-threatening injuries.

The truck driver was not hurt.