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Kirk Cousins connected with rookie Jordan Addison for two first-half touchdowns, Camryn Bynum intercepted San Francisco's Brock Purdy twice in the fourth quarter, and the Minnesota Vikings beat the 49ers 22-17.
San Francisco's George Kittle likes to say he's from "Tight End University.".
Rookie Tyson Bagent led three touchdown drives with Justin Fields sidelined, D'Onta Foreman ran for two scores and caught a TD pass, and the Chicago Bears beat the Las Vegas Raiders 30-12 on Sunday.
Brock Purdy finds himself in an usual spot.
Christian McCaffrey, Deebo Samuel and Trent Williams all missed practice for the San Francisco 49ers on Thursday and their status for this week's game against Minnesota is in doubt.
With Deebo Samuel missing most of the game with a shoulder injury and Christian McCaffrey sidelined halfway through the game with an injured oblique and rib, the 49ers struggled for most of the second half in a 19-17 loss to the Browns on Sunday.
The National Football League has reportedly fined San Francisco 49ers tight end George Kittle more than $13,000 for wearing a profane T-shirt poking fun at the Dallas Cowboys.
Deshaun Watson of the Cleveland Browns didn't practice all week and was officially ruled out Friday as his teammates prepared for the San Francisco 49ers (5-0).
Going into Sunday's game against Cleveland's top-ranked defense, Purdy leads the league in passer rating while completing 72.1% of his passes.
Browns quarterback Deshaun Watson still isn't practicing and it's starting to look as if he won't play Sunday against San Francisco.
Kyle Shanahan and Mike McDaniel spent years together scheming ways to exploit NFL defenses.
Postgame reaction from the 49ers locker room after they blew out the Cowboys 42-10 on Sunday night to stay unbeaten this season. (10-9-23)
When the San Francisco 49ers dealt a bevy of draft picks to Carolina last October for Christian McCaffrey, some skeptics asked whether they overpaid for a running back in a passing league.
Kyle Shanahan grew up around the NFL following his father from stop to stop on the coaching carousel before getting on it himself so he knows full well how rare it is to have a long stay at one spot.
Colin Kaepernick, who last played in the NFL in 2016, wrote in his letter to the Jets that he "never retired or stopped training" in hopes of getting another opportunity.
The Pittsburgh Steelers walked into the bright lights of Sin City Sunday night and came out the other side with a 23-18 win against the Las Vegas Raiders.
Three straight wins with 30 points scored in each game is just the kind of start the San Francisco 49ers wanted to have this year after being forced to climb out of early holes the past two years.
Niners fans who showed up for Thursday's home opener did not leave Levi's Stadium disappointed. Jocelyn Moran reports. (9-21-23)
Matt Lively reports from Sofi Stadium where the 49ers won their eighth straight reagular season game over the Rams to move to 2-0 on the season.
Though the season-opening road trip couldn't have gone much better for the San Francisco 49ers, coach Kyle Shanahan still sees plenty of things that need to be fixed.
The San Francisco 49ers hung on for their ninth consecutive regular-season victory over the Los Angeles Rams.
San Francisco has eight consecutive regular-season victories over the Rams, who host the Niners again on Sunday in a meeting of 1-0 teams.
Aaron Rodgers was injured on his fourth snap in his debut with the New York Jets, needing to be carted from the sideline with an ankle injury Monday night.
49ers quarterback Brock Purdy spoke to reporters after the Niners defeated the Steelers Sunday in Pittsburgh. (9-10-23)
Brock Purdy has been on quite a ride since entering the NFL as the final pick of the 2022 draft.
