SEATTLE (AP) -- Russell Wilson threw four more touchdown passes, two to DK Metcalf, and the Seattle Seahawks rebounded from their first loss of the season with a resounding 37-27 win over the San Francisco 49ers on Sunday.
Wilson and Metcalf tormented San Francisco and its banged up secondary as the top-scoring offense in the league continued to pile up points. The Seahawks (6-1) have scored at least 30 points in six of seven games.
Wilson hit Metcalf on a pair of first-half touchdown passes, but it was a 2½-minute sequence midway through the third quarter when Seattle blew the game open.
Wilson found rookie DeeJay Dallas on a 2-yard TD pass after San Francisco went three-and-out to open the second half for a 20-7 lead. Dante Pettis fumbled the ensuing kickoff on a big hit from Cody Barton. Six plays later, Wilson evaded pressure in the pocket and zipped a 6-yard TD pas to David Moore for a 27-7 lead.
Seattle added one more score on a 1-yard TD run by Dallas with 3:33 left after the 49ers pulled within 10.
Wilson finished 27 of 37 for 261 yards and has 26 TD passes on the season, one behind Tom Brady for the most in the first seven games of a season.
Metcalf had another career day in his breakout second season. Metcalf had 102 yards receiving in the first half and finished with a career-high 12 catches and 161 yards receiving.
The momentum from two straight wins for San Francisco (4-4) evaporated in a hurry as more injuries continued to pile up. Jimmy Garoppolo was just 11 of 16 for 84 yards and an ugly interception in the first quarter. Garoppolo went to the locker room with an ankle injury early in the fourth quarter and was replaced by Nick Mullens.
Running back Tevin Coleman returned for the first time since early in the season, only to leave at halftime with a knee injury. George Kittle made a terrific 25-yard catch early in the fourth quarter, but limped to the locker room with a foot injury.
Mullens led San Francisco on three TD drives in the fourth quarter. He capped the second with a 16-yard TD pass to Ross Dwelley with 4:16 left, but the 2-point conversion failed after replay ruled Jerick McKinnon was touched down short of the goal line.
Mullens was 18 of 25 for 238 yards and two touchdowns. Seattle's league-worst defense had shut down the 49ers for three quarters before giving up 20 fourth-quarter points.
Seattle sacked Garoppolo three times — two by Bobby Wagner — a week after failing to record a QB hit on Arizona's Kyler Murray.
Metcalf's big day took off when he added another clip to his highlight reel catching a short pass and racing 46 yards for a TD on the final play of the first quarter. On Metcalf's second TD, Moseley was flagged for interference but couldn't keep Metcalf's size and strength from still making the catch.
Metcalf's previous career highs came in last year's playoff win over Philadelphia when he had seven catches for 160 yards.
The Seahawks played without five starters and one key backup. Chris Carson, Carlos Hyde, Jamal Adams, Benson Mayowa, Ugo Amadi and Mike Iuptai were all inactive due to injuries.
San Francisco played without starters Deebo Samuel, Jeff Wilson Jr., Kwon Alexander and safety Jaquiski Tartt.
49ers: have a quick turnaround and will host Green Bay on Thursday night.
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