49ers QB Brock Purdy set for "aggressive" practice; aims to start vs. Cardinals

San Francisco 49ers quarterback Brock Purdy is set for an aggressive practice on Wednesday.

• Nov 12, 2025

Matthew Stafford throws 4 TDs as Rams beat 49ers 42-26 for their 4th straight win

Matthew Stafford throws four touchdown passes, setting a Rams franchise record for the most in a three-game span.

• Nov 9, 2025

49ers missing another defensive starter vs. Rams in NFC West showdown; Purdy won't start

The San Francisco 49ers lost another key defensive player for the season when rookie Mykel Williams went down with a knee injury.

• Nov 7, 2025

49ers' Mykel Williams out for season with torn ACL as injury woes mount

San Francisco 49ers defensive lineman Mykel Williams will miss the rest of the season after the first-round pick was diagnosed with torn ligaments in his right knee.

• Nov 3, 2025

Christian McCaffrey, 49ers aim to get back on track against New York Giants

Christian McCaffrey and the San Francisco 49ers hope to get back on track running the ball against the New York Giants and their 30th-ranked rush defense.

• Oct 31, 2025

Christian McCaffrey's 200-yard game from scrimmage powers 49ers past Falcons 20-10

Christian McCaffrey has his first 100-yard rushing game since 2023, helping the San Francisco 49ers beat the Atlanta Falcons 20-10 on Sunday night.

• Oct 19, 2025

49ers activate star tight end George Kittle from injured reserve ahead of Falcons game

The San Francisco 49ers have activated star tight end George Kittle from injured reserve.

• Oct 18, 2025

49ers' Purdy out for 3rd straight game, Mac Jones to start against Falcons

Quarterback Brock Purdy has been officially ruled out of his third straight game for the San Francisco 49ers with a toe injury and Mac Jones will start against the Atlanta Falcons.

• Oct 17, 2025

49ers All-Pro linebacker Fred Warner out for season following gruesome ankle injury

Four-time All-Pro linebacker Fred Warner will need season-ending surgery after he was sidelined by a severe ankle injury during San Francisco's loss to Tampa Bay.

• Oct 12, 2025

Baker Mayfield tosses 2 touchdown passes, Buccaneers beat the 49ers 30-19

Baker Mayfield's heroics came early in the fourth quarter instead of the final minutes.

• Oct 12, 2025

49ers' Brock Purdy out again, Mac Jones questionable but expected to start

Quarterback Brock Purdy will miss his fourth game this season for San Francisco due to a toe injury.

• Oct 10, 2025

49ers kicker Eddy Piñeiro named NFC Special Teams Player of the Week

Eddy Piñeiro has quickly become a fan favorite with the San Francisco 49ers.

• Oct 8, 2025

Brock Purdy misses practice due to toe injury as 49ers prepare for Buccaneers

San Francisco 49ers quarterback Brock Purdy is still sidelined by a toe injury and missed practice on Wednesday.

• Oct 8, 2025

Short-handed 49ers stop Rams on downs in OT, winning 26-23

Eddy Piñeiro hit a 41-yard field goal in overtime before the San Francisco defense stopped Kyren Williams on fourth down with 3:36 to play, and the short-handed 49ers hung on for a thrilling 26-23 victory over the Los Angeles Rams on Thursday night.

• Oct 2, 2025

49ers' Purdy, Pearsall, Jennings ruled out for Rams game Thursday with injuries

The injury-ravaged San Francisco 49ers will again be missing multiple starters with injuries for the Thursday night game against the Los Angeles Rams.

• Oct 1, 2025

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