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The 49ers' rookie quarterback Trey Lance had an up-and-down first start, making some impressive plays with his arm and feet, but San Francisco fell to the Arizona Cardinals 17-10 on Sunday.
Russell Wilson overcame a shaky start to throw for two touchdowns and run for a third and the Seattle Seahawks rebounded from back-to-back losses by beating the San Francisco 49ers 28-21 on Sunday.
The mounting injuries at running back and cornerback finally caught up to the San Francisco 49ers in their last second-loss to the Green Bay Packers.
Aaron Rodgers completed two deep passes to Davante Adams on a last-minute drive, setting up Mason Crosby's 51-yard field goal on the final play of the game that gave the Green Bay Packers a 30-28 victory over the San Francisco 49ers on Sunday night.
The San Francisco 49ers' season-opening road trip featured a few key injuries, a near fourth-quarter collapse and an ugly offensive performance.
Jimmy Garoppolo wasn't thinking about Trey Lance coming into the game. He was too busy using his own legs to convert first downs. Garoppolo threw one touchdown pass and ran in for a score, leading the San Francisco 49ers to a 17-11 victory over the Philadelphia Eagles on Sunday.
Dre Greenlaw returned an interception for a touchdown to help the San Francisco 49ers score 17 points over two-plus minutes late in the first half, and they barely held on for a 41-33 win over the Detroit Lions on Sunday.
The San Francisco 49ers got a chance to show off their quarterback platoon before the regular season.
Trey Lance's bid to be the San Francisco 49ers' starting quarterback was a bit of a rollercoaster Sunday night, but the rookie rebounded from a rough start to keep his hopes alive.
A lot of eyes have been on Lance ever since the 49ers drafted him in April after trading three first-round picks for the No. 3 selection.
Jimmy Garoppolo's future with the San Francisco 49ers immediately became a bit cloudy when the San Francisco 49ers traded up to draft Trey Lance with the No. 3 overall pick.
The San Francisco 49ers lost two more backups to significant injuries during offseason workouts.
San Francisco 49ers center Weston Richburg has retired after a knee injury derailed his career.
San Francisco 49ers running back Jeff Wilson Jr. will miss the start of the 2021 season after undergoing surgery on his injured knee.
Lance looked comfortable running drills and 7-on-7 sessions, completing 20 of 24 passes in those drills with most being of the shorter variety. His best pass was a completion in traffic over the middle to tryout receiver Marqise Lee, who has played 59 career games in the NFL.
